Table 3. Characteristics of Liquid-Type PDO and CaHA Products

No	Product name	Manufacturer (Country)	Principal component	Formulation	Volume	Excipients	Anesthetic	Injection method	Indications	MFDS§ approval	International certification
1	ULTRACOL	LIV Co., Ltd. (Korea)	PDO§	Powder	(PDO+SCMC): 50·100·150·200 ㎎/vial	SCMC§	None	25G needle/25G cannula	Nasolabial folds	Tissue repair material (No. 20-598, 2020.07.22)	CE§(2021)
2	RADIESSE + Lidocaine*	Merz North America, Inc. (USA)	CaHA§	Suspension	1.5 ㎖/syringe	SCMC	Lidocaine hydrochloride0.3% (pre-mixed)	27G needle (PFS§)	Facial wrinkles(nasolabial folds, marionette lines, jawline), cheek volume augmentation, dorsal hand wrinkles	Tissue repair material (No. 17-91, 2017.03.07)	FDA§ (2009), CE (2016)
3	VOLassom, Facetem, etc.†	CGBIO (Korea)	CaHA	Suspension	0.3·0.8·1.0·1.5 ㎖/syringe	SCMC, glycerin, water	None	Injection (PFS)	Facial wrinkles	Tissue repair material (No. 11-1324, 2011.12.05)	CE (2020)
4	RADIESSE‡	Merz North America, Inc. (USA)	CaHA	Suspension	1.5 ㎖/syringe	Gel, sterile distilled water for injection, glycerol, SCMC	None	27G needle or larger diameter	Facial wrinkles(nasolabial folds), cheek volume augmentation, dorsal hand volume restoration, HIV-associated facial fat loss	Tissue repair material (No. 10-1238, 2010.11.17)	FDA (2006), CE (2004)

Model name: RADIESSE + Lidocaine InjecTable Implant 1.5㎖ (also known as RADIESSE WITH LIDOCAINE).
All product names under this approval: VOLassom, Facetem, NUIT, Facetem S, VOLassom CaHA, DCLASSY CaHA 0.8/1.5.
Model name: RADIESSE InjecTable Implant 1.5㎖.
PDO, polydioxanone; CaHA, calcium hydroxyapatite; SCMC, sodium carboxymethylcellulose; MFDS, Ministry of Food and Drug Safety; CE, Conformité Européenne; FDA, Food and Drug Administration; PFS, prefilled syringe.