| Luo(2024)28) | 120(60:60) | T: 33/27C: 35/25 | T: 54±4(18-60)C: 54±4(18-60) | T: 4.41±1.08(d)(2-7d)C: 4.36±1.15(d)(2-7d) | 2-7d | NR |
| Zhang(2024)29) | 66(33:33) | T: 13/20C: 10/23 | T: 53.00(47-58)C: 56.00(44-62) | T: 22(d)(15-30d)C: 30(d)(20-30d) | 15-90d | NR |
| Jiang(2023)30) | 132(66:66) | T: 22/44C: 28/38 | T: 48.12±12.74C: 44.21±12.17 | NR | Within 2m | NR |
| Tao(2023)31) | 80(40:40)Drop out 1:1 | T: 19/20C: 17/22 | T: 47±12(19-59)C: 47±13(20-58) | T: 6.3±2.3(d)(2-10d)C: 5.9±2.1(d)(2-9d) | Within 10d | NR |
| Wei(2022)32) | 60(30:30) | T : 19/11C : 18/12 | T : 34.82±16.21(18-70)C : 35.43±14.56(18-70) | T : 12.08±3.54(d)(3-29d)C : 11.25±4.32(d)(3-28d) | NR | NR |
| Liang(2021)33) | 90(30:30:30) | T1: 12/18T2: 15/15C: 14/16 | T1: 32.30±6.02T2: 33.70±5.85C: 32.70±6.20 | T1: 8.20±3.61(d)T2: 8.00±3.58(d)C: 7.90±3.69(d) | 3h-2w | NR |
| Jiang(2021)34) | 118(30:30:31:27)Drop out 1:0:0:1 | T1: 12/17T2: 15/15T3: 17/14C: 16/10 | T1: 53±11(23-74)T2: 51±13(22-72)T3: 52±13(26-74)C: 52±13(22-74) | T1: 12.1±7.3(d) (0.5-29d)T2: 10.2±5.1(d)(1-20d)T3: 10.4±5.1(d)(1-20d)C: 11.3±6.2(d)(1-20d) | Within 1m | Mild/Moderate/Severe/Extremly heavyT1:8/8/9/4T2:1/10/6/13T3:6/14/4/7C:5/7/8/6 |
| Sun(2021)35) | 100(50:50) | T : 25/25C : 20/30 | T : 45.8±8.4(30-70)C : 45.2±7.8(32-69) | T : 8.3±2.8(m)(5-12m)C : 7.3±3.5(m)(3-12m) | NR | Mild/Moderate/SevereT:8/30/12C:8/35/5 |
| Zhang(2020)36) | 100(50:50) | T: 24/26C: 22/28 | T: 39.96±12.72C: 41.34±11.55 | T: 7.41±2.62(d)C: 7.27±2.25(d) | 2-14d | Mild/Moderate/Severe/Extremly heavy/Totally deafT:17/15/13/3/2C:19/16/11/2/2Low/High/FullT:20/19/11C:24/17/9 |
| Sheng(2020)37) | 78(39:39) | T: 19/20C: 21/18 | T: 40±1 (20-66)C: 42±13(21-68) | T: 20.4±3.5(d) (14-28d)C: 20.6±3.5(d)(14-28d) | 14-28d | Moderate/Moderate-severe/SevereT:20/14/5C:17/21/1 |
| Fan(2020)38) | 105(35:35:35) | T1: 18/17T2: 16/19C: 17/18 | T1: 45.94±10.47T2: 47.06±9.53C: 48.06±11.45 | T1: 7.46±3.85(d)T2: 6.91±3.51(d)C: 6.31±3.78(d) | Within 2w | NR |
| Ju(2020)39) | 72(36:36) | T: -C: - | T: 37.89±0.06(18-72)C: 36.36±0.03(18-72) | NR | NR | NR |
| Lu(2019)40) | 300(150:150) | T: 82/68C: 80/70 | T: 41.82±5.48C: 42.19±5.63 | NR | NR | NR |
| Gao(2019)41) | 110(55:55) | T: 29/26C: 30/25 | T: 46.62±6.25(18-68)C: 46.78±6.37(19-70) | NR | NR | NR |
| Gong(2018)42) | 37(20:17) | 25/17 | A; 53.4±10.3(45-70) | A: 1d-3m | NR | NR |
| Zhao(2017)43) | 60(30:30) | T: 19/11C: 20/10 | T: 57±13C: 58±12 | T : 47.67±25.53(h)C: 48.53±24.44(h) | NR | Mild/Moderate/SevereT:12/12/6C:11/12/7 |
| Liang(2017)44) | 103(51:52) | T: 17/34C: 19/33 | T: 32.30±4.70C: 32.70±3.90 | T: 8.20±3.60(d)C: 7.90±3.70(d) | Within 2w | NR |
| Guo(2016)45) | 60(30:30) | T: 31/32C: 21/24 | T: 38.5±11.7C: 39.1±10.8 | T: 5.3±2.6(d)(1-12d)C: 5.4±2.7(d)(1-13d) | Within 2w | NR |
| Yang(2016)46) | 90(45:45) | T: 21/24C: 21/24 | T: 37.98±11.15(18-68)C: 37.05±10.72(18-65) | T: 14.63±5.62(d)(2-26d)C: 13.72±4.23(d)(1-25d) | NR | NR |
| Liu(2015)47) | 60(30:30) | T: 18/12C: 21/9 | A; 46(17-65) | A: 3d-1m | NR | NR |
| Huang(2014)48) | 112(59:53) | T : 33/26C : 29/24 | T: 37.0±5.6C: 38.0±4.9 | T :18.0±3.5(d)(10-30d)C: 19.0±4.2(d)(10-30d) | Within 30d | NR |
| Liang(2014)49) | 60(30:30) | T: 14/16C: 13/17 | T: 33.80±12.03C: 31.53±11.69 | T: 3.82±1.10(d)C: 3.72±1.08(d) | Within 2w | Mild/Moderate/Moderate to severe/SevereT: 5/9/11/5C: 6/8/10/6 |
| Xu(2013)50) | 62(30:32) | T: 19/11C: 20/12 | T: 44.2±2.4(23-71)C: 45.5±2.0(16-73) | T: 1d-5yC: 2d-4y | NR | Mild/Moderate/Moderate to severe/Severe/Hearing lossT: 2/5/11/7/4C: 1/11/11/7/2 |
| Luo(2012)51) | 188(74:56:58) | T1: 38/36T2: 28/28C: 28/30 | T1: 49±７(31-61)T2: 49±6(35-63)C: 48±6(32-58) | T1: 13.2±3.8(d)(3-22d)T2: 12.2±3.9(d)(1-20d)C: 12.7±3.9(d)(2-21d) | Within 1m | Mild/Moderate/SevereT1: 24/25/25T2: 19/20/17C: 20/20/18 |
| Qiu(2012)52) | 60(30:30)Drop out 2:0Affected ear 34:32 | T: 6/22C: 10/20 | T: 42.6±13.5(14-62)C: 42.8±13.4(15-64) | T: 4.5±19.5(d)(1-45d)C: 7.0±5.2(d)(1-15d) | NR | NR |
| Chen(2011)53) | 100(50:50) | T: 26/24C: 24/26 | T: 33±11C: 32±11 | <1d/1-7d/>7dT: 17/26/7C: 19/23/8 | NR | Mild/Moderate/Moderate to severe/Severe/Hearing lossT:6/22/16/5/1C:7/21/15/6/1 |
| Wu(2010)54) | Affected ear 69:53 | T: 44/25C: 32/21 | T: 15-77C: 15-77 | NR | NR | Mild/Moderate/Moderate to severe/Severe/Hearing lossT: 11/12/18/15/13C: 8/10/15/10/10 |
| Luo(2009)55) | 60(30:30) | T: 15/15C: 15/15 | T: 50.3±4.4C: 51.2±5.1 | T: 2.1±0.1(w)C: 2.2±0.2(w)A: 1d-4w | NR | NR |