Table 2. Summary of Included Chronic Rhinosinusitis Studies

First Author (Year) Sample size(T/C);Sex(F/M); Age(Mean±SD yr); Duration of disease Treatment Group Control Group Outcome Measures Period Adverse Events
杨丽 (2010)12) 52(26/26);T:9/17; 38.65±10.881; NRC:8/18; 34.81±10.450; NR 1.CHM(ultrasonic inhalation, tid) 1.distilled water(ultrasonic inhalation, tid) 1.VAS2.MTT 7d No adverse events
王爱民 (2010)13) 210(70/70/70);N:76/134; 6.8;4wk-3.5yr T1 : 1.Xoingdan Tongbi(nasal spray, bid) plus CT2: 1.Fluticasone propionate (nasal spray, bid) plus C 1.pharmacotherapy (oral) 1.Effective rate 2wk NR
苏应东 (2012)14) 496(250/246);N:215/281; 30;1-22yr 1.CHM(ultrasonic inhalation, bid) 1.Fangzhi Biyan Pian (oral, tid) 1.Effective rate 10d NR
王刚 (2013)15) 98(49/49); NR;10.4±2.6; ≥3mon 1.Ma yi bi yan spray(nasal spray, tid) plus C 1.cefuroxime or roxithromycin 1.Effective rate2.VAS3.SNOT-204.Lund-Kennedy 20d NR
唐思晨 (2019)16) 72(36/36);T:12/24; 35.5±10.4; 7.7±3.2monC:15/21; 36.3±10.3; 7.8±2.9mon 1.Longdan Xiegan Decoction (fumigation, bid) 1.nomal saline (fumigation, bid) 1.Effective rate2.VAS3.MTR 28d No adverse events
吴紫陆 (2021)17) 168(84/84);T:43/41; 8.28±1.76; 5.40±0.94monC:39/45; 9.62±2.19;5.21±1.13mon 1.Bikangfu(nasal administration, qd) 1.Tongqiao Biyan granules(oral, tid)2.Sinupret® (oral, tid) 1.Effective rate2.VAS3.Lund-Mackay4.Symptom score5.Levels of inflammatory factors in serum and nasal secretions NR Mild rashes: T(0), C(2)
毛新桐 (2021)18) 60(30/30);T:13/17; 39.83±14.61; 2.30±1.99yrC:16/14; 38.60±12.92; 1.66±1.23yr 1.Shenlingbaizhu Powder(oral, bid)2.Shenlingbaizhu Powder(steam inhalation, bid) 1.Shenlingbaizhu Powder(oral, bid)2.water(steam inhalation, bid) 1.Lund-Kennedy2.Symptom score NR NR
艾斌 (2021)19) 220(110/110);T:54/56; 39.15±1.46; NRC:55/55; 39.57±1.37; NR 1.Cang er zi san modified(ultrasonic inhalation, qd) 1.budesonide (nasal spray, bid)2.roxithromycin (oral, bid) 1.Effective rate 4wk NR
Abbreviations: CRS: chronic rhinosinusitis; T: treatment group; C: control group; F: female; M: male; yrs: years; d: days; tid: three times a day; MTT: mucociliary transport time; NR: not reported; wk: week; bid: two times a day; SNOT: sino-nasal outcome test; MTR: mucociliary transport rate