Table 2. Characteristics of Clinical Studies of Traditional Korean Medicine on Olfactory Dysfunction

First Author (Year) Type of Olfactory Dysfunction Treatment intervention (TG) Control intervention (CG) Treatment period
Herbal medicine Acupuncture Treatment Additional interventions
Randomized controlled trial
Jiang et al. 21) (2023) Post-traumatic Guizhi-tang (桂枝湯), TID NA OT OT 6M
Drews et al. 10) (2022) Post-viral NA 2 times/week12 sessions in totalDuration 30minAcupoint (LI20, LI4, SP6, ST44, Bl 3, LG23, NP 12, Op 16,) NA Sham acupuncture2times/week,12 sessions in totalDuration 30minAcupoint (fake acupuncture point at Deltoideous, Upper Arm, Thigh, Back) 6W
Retrospective cohort study
Vent, et al 22) (2010) Post-viral NA 1time/week,10 sessions in totalDuration 30minAcupoint (GV16, GV20, LI20, LU7, LU9, ST36, KI3) NA oral vitamin B complexover 12 weeks TG :10WCG:12W
Ono et al. 4) (2022) Post-viral (COVID-19) Used multiple formulas in combination a NA Partially combined with WM b Some untreated(n=11),some received WM(n=24) NR
Retrospective observational study
Park, et al 12) (2019) post-viral, sinonasal, traumatic, unknown Tongqiao Tang (通竅湯)Jiantong Daotan Tang (肩痛導痰湯)Xuanfang Baidu Tang (宣方敗毒湯)Buxin Jianpi Tang (補心健脾湯)TID 1-2times/week,Duration 15minAcupoint (GV20, GV23, EX-HN3, LI20, GB20, CV21, BL1, LU7, LI4, LI11, SI3, ST36, SP6, LR3) - Electro-moxibustion applied to bilateralLI20 and GV20 for 10 minutes,1–2 times/week- Intranasal administration of anti-inflammatory herbal extract (0.25 cc per nostril),1–2 times/week- OT for 12 weeks NA 12W
Case report
Im, et al 16) (2024) Unspecified Mahuang-jia-Zhushu Tang (麻黃加朮湯)BID 5 sessions in totalDuration 20minAcupoint (LI20, EX-HN8, LI4, ST36, SI3) NA NA 35D
Bhat et al. 11) (2023) Post-viral (COVID-19) NA 7 sessions in totalDuration 20minAcupoint (GV20, LI20, Ex-HN3, HT7, LI11, GB8, GB21, GV25) Ayurvedic therapy: Shadbindu taila marsha nasya for 7 days, followed by pratimarsha nasya for 4 months + oral intake of Naradiya Laxmivilasa Rasa (TID for 1 month)" NA
Morita et al. 13) (2022) Post-viral (COVID-19) C1: Jiawei Guipi Tang (加味歸脾湯)C2: Renshen Yangrong Tang (人蔘養榮湯) 1-2times/week,Duration 15minAcupoint (LI20, HT7, SP9, BL10, BL14, BL15, KI3, PC6, PC7, GB20, LR3, CV7, GV12, GV20) NA NA 7-8 M
Takayama et al. 5)(2021) Post-viral (COVID-19) Gegen-tangjia Chuanxiong Xinyi (葛根湯加川芎辛夷)7.5 g/day (divided into 3 doses) NA NA NA 3-5 D
Hunter, et al 17) (2021) Post-viral NA 6 sessions2–4 week intervalsDuration 10minAcupoint (BL2, LI20, CV24, GV20, GV22, GV24, GV26, EX-HN3) NA NA 3M
Kang, et al 18) (2018) Sinonasal (chronic rhinosinusitis) C1:- Tongqiao Tang (通竅湯) BID~TID- Jingfang Xiebai San(荊防瀉白散) BID,- Qingyin Lige Tang(淸因理膈湯)QDC2- Used multiple formulas in combination cTID or BID depending on prescription 2 times/week,15 Sessions in totalDuration 15 minAcupoint (EX-B2 (C3-7), GV14, GV13, BL11, LI20, EX-HN8, EX-HN9, ST7) NA NA C1:2MC2: 10W
Jeon et al.19) (2017) Post-viral, Sinonasal C1 :- Jingjie Lianqiao Tang (荊芥連翹湯), - Bofu-tsusho-san (防風通聖散) (4g, BID)C2 : Jiawei Erchen Tang (加味二陳湯) (120cc, BID) 1-2times/weekDuration 15 minAcupoint (EX-HN3, LI20, Intranasal acupuncture) Nasal lasers irradiated for 5minutes1-2times/week NA C1: 55DC2: 23D
Moon et al.20)(2017) Post-viral, Danggui Shaoyao San (當歸芍藥散) TID 1time/week15 sessions in totalDuration 15 minAcupoint (Ex-HN3, GV20, GV23, LI4, LR3, LI20, EX-HN8) NA NA 95D
D : Days, W : Weeks, M : Months, OT : Olfactory treatment, BID : Bis in die, TID : Ter in die, WM : Western medicine, TG : Treatment Group, CG : Control Group, C : Case
Jingjie Lianqiao Tang (荊芥連翹湯), Xiaochaihu-tangjia Jiegeng Shigao (小柴胡湯加桔梗石膏), Gegen-tangjia Chuanxiong Xinyi (葛根湯加川芎辛夷), Gegen Tang (葛根湯), Wuhu Tang (五虎湯), Sairei-to (柴苓湯), Xiaochaihu Tang (小柴胡湯), Chaiqian Tang (柴陷湯), Jiegeng Shigao Tang (桔梗石膏湯), Wuling San (五苓散), Sansu-yin (三素飲), Zhuye Wendan Tang (竹葉溫膽湯), Maimendong Tang (麥門冬湯), Danggui Shaoyao San (當歸芍藥散)
Acetaminophen, Dimemorfan phosphate, Carbocistein, Tulobuterol, Tranexamic acid, Fexofenadine Hydrochloride, Multi-ingredient cold medication, Brotizolam, Loxoprofen, Lactomin
Ssanghwa-tanghe Xuanfang Baidu Tang (雙和湯合宣方敗毒湯), Tongbi Dan (通痺丹), Yangwei Jianfei Tang (養胃健肺湯), Daqinglong Tang (大青龍湯), Qingshang Buhe Tang (淸上補下湯), Jiawei Ssanghwa Tang (加味雙和湯), Tongqiao Tang (通竅湯)