| Yang W9) (2015) | Radiation induced | T* : 30C† : 30 | T : Yangyin Qingfei DecoctionC : Artificial saliva (4% methylcellulose solution) | 14 days | 1) TER‡ | TER (p<0.05)T : 83.3%C : 36.7% | NR§ |
| Wang J10) (2015) | Radiation induced | T : 30C : 30 | T : Jiaweizengye DecoctionC : None | NR | 1) Xerostomia score2) Salivary secretion | Xerostomia score (p<0.05): T < CTotal unstimulated salivary (p<0.05)T : 14.3 ± 4.0 → 5.4 ± 1.3 → 7.1 ± 2.0C : 14.1 ± 4.9 → 2.4 ± 0.1 → 2.5 ± 0.5 | NR |
| Wei N11) (2016) | Sjogren’s syndrome | T : 33C : 32 | T : TCM∥C : Pilocarpine | 4 weeks | 1) TER2) XQ¶3) Unstimulated salivary flow rate4) Cube sugar test5) Serological index | TER (p>0.05)T : 72.73%C : 65.63%XQ score (p>0.05)T : 8.61 ± 2.46 → 5.03 ± 1.01C : 7.98 ± 2.87 → 4.89 ± 1.12Unstimulated salivary flow rate (p<0.05)T : 0.52 ± 0.36 → 1.05 ± 0.57C : 0.55 ± 0.21 → 0.68 ± 0.47Cube sugar test score (p<0.05)T : 7.89 ± 3.68 → 5.61 ± 2.87C : 8.22 ± 3.52 → 6.73 ± 4.28ESR (p>0.05)T : 31.11 ± 10.60 → 29.28 ± 11.64C : 30.19 ± 11.29 → 30.35 ± 9.16CRP (p>0.05)T : 38.16 ± 7.88 → 19.53 ± 6.01C : 36.68 ± 6.94 → 33.31 ± 5.47IgG (p>0.05)T : 20.72 ± 3.38 → 18.84 ± 4.19C : 18.78 ± 4.16 → 17.53 ± 6.35IgM (p>0.05)T : 1.54 ± 0.29 → 1.55 ± 0.34C : 1.66 ± 0.73 → 1.63 ± 0.47IgA (p>0.05)T : 3.36 ± 0.29 → 3.27 ± 0.56C : 3.79 ± 0.33 → 3.68 ± 0.52 | NR |
| Nie Y12) (2016) | Sjogren’s syndrome | T : 42C : 42 | T : Lushi Runzao DecoctionC : Hydroxychloroquine | 3 months | 1) TER2) Serological index3) Unstimulated salivary flow rate4) VAS5) TCM syndrome | TER (p<0.05)T : 97.62%C : 85.71%RF (p<0.05)T : 77.16 ± 16.38 → 32.53 ± 11.46C : 77.23 ± 16.43 → 44.38 ± 11.53ESR (p<0.05)T : 54.74 ± 9.82 → 10.73 ± 2.75C : 54.82 ± 9.92 → 12.78 ± 3.54CRP (p<0.05)T : 24.57 ± 6.58 → 8.65 ± 2.24C : 24.59 ± 6.61 → 12.14 ± 3.36Unstimulated salivary flow rate (p<0.05)T : 0.63 ± 0.33 → 4.25 ± 1.26C : 0.64 ± 0.32 → 3.02 ± 1.18VAS (p<0.05)T : 5.65 ± 1.32 → 3.23 ± 1.25C : 5.67 ± 1.34 → 4.52 ± 1.28TCM syndrome (p<0.05)T : 19.78 ± 3.56 → 12.43 ± 3.65C : 19.77 ± 3.54 → 14.72 ± 3.69 | No serious adverse reactions |
| Hao Q13) (2016) | Radiation induced | T : 27C : 24 | T : Yu’nv Decoction + CC : Dober’s gargle solution + dexamethasone + gentamicin + 0.9% sodium chloride | 7 weeks | 1) Oral mucosal reaction2) Xerostomia score | Oral mucosal reaction (p<0.05): T < CXerostomia score (p<0.05): T < C | NR |
| Li Y14) (2017) | Maintenance hemodialysis | T : 50C : 50 | T : TCM + CC : Cyclophosphamide | 4 weeks | 1) TCM syndrome2) XQ3) Dialysis water loss4) Aquaporin-55) TER | Integral of xerostomia and throat (p<0.05)T : 4.25 ± 1.00 → 0.76 ± 0.17C : 4.30 ± 1.03 → 1.47 ± 0.46Red eyes and upset (p<0.05)T : 4.29 ± 0.98 → 0.78 ± 0.20C : 4.22 ± 0.95 → 1.45 ± 0.38Dry cough (p<0.05)T : 4.03 ± 0.94 → 0.70 ± 0.21C : 3.96 ± 0.97 → 1.36 ± 0.39Two cheek swelling (p<0.05)T : 3.82 ± 0.82 → 0.63 ± 0.19C : 3.87 ± 0.84 → 1.39 ± 0.37Pale tongue (p<0.05)T : 3.79 ± 0.82 → 0.73 ± 0.20C : 3.71 ± 0.87 → 1.42 ± 0.36Pulse floating number (p<0.05)T : 3.86 ± 0.84 → 0.79 ± 0.16C : 3.79 ± 0.81 → 1.45 ± 0.40XQ score (p<0.05)T : 27.93 ± 4.28 → 8.16 ± 2.24C : 27.78 ± 4.22 → 14.40 ± 3.17Dialysis water loss (p<0.05)T : 2.91 ± 0.63 → 2.16 ± 0.33C : 2.95 ± 0.65 → 2.68 ± 0.50Aquaporin-5 (p<0.05)T : 1.22 ± 0.33 → 1.97 ± 0.50C : 1.18 ± 0.31 → 1.46 ± 0.42TER (p<0.05)T : 94.00%C : 72.00% | No serious adverse reactions |
| Huang Z15) (2018) | None | T : 45C : 44 | T : Zengye Decoction + CC : Vitamin C, B complex + human epidermal factor | 14 days | 1) TER2) Salivary secretion3) Recurrence rate | TER (p<0.05)T : 95.56%C : 79.55%Unstimulated salivary flow rate (p<0.05)T : 0.23 ± 0.14 → 0.57 ± 0.22C : 0.22 ± 0.17 → 0.39 ± 0.20Total unstimulated salivary (p<0.05)T : 2.86 ± 1.47 → 7.21 ± 3.58C : 2.88 ± 1.65 → 4.34 ± 2.01Stimulated salivary flow rate (p<0.05)T : 1.03 ± 0.32 → 2.67 ± 1.23C : 1.01 ± 0.35 → 1.84 ± 0.39Total stimulated salivary (p<0.05)T : 5.69 ± 2.08 → 14.67 ± 5.84C : 5.70 ± 2.11 → 8.97 ± 3.21Recurrence rate (p>0.05): T < C | No serious adverse reactions |
| Jin J16) (2019) | Radiation induced | T : 50C : 50 | T : Zhigancao DecoctionC : Placebo | 6 months | 1) VAS2) EF3) Serological index | VAS (p<0.05): T < CEF (p<0.05): T > CIL-17 (p<0.05): T < CIL-10 (p<0.05): T > C | No serious adverse reactions |
| Li R17) (2019) | Sjogren’s syndrome | T : 20C : 20 | T : TCM + iguratimodC : Hydroxychloroquine + total peony glycoside | 12 weeks | 1) TER2) Serological index3) Unstimulated salivary flow rate | TER (p<0.05)T : 90%C : 50%ESR (p<0.05)T : 34.27 ± 8.38 → 23.21 ± 5.69C : 38.35 ± 5.56 → 28.87 ± 7.35CRP (p<0.05)T : 18.41 ± 8.25 → 3.47 ± 3.16C : 17.94 ± 2.53 → 11.28 ± 5.33IgG (p<0.05)T : 27.24 ± 2.21 → 19.35 ± 3.57C : 26.54 ± 5.85 → 20.47 ± 4.78IgM (p<0.05)T : 1.53 ± 0.47 → 1.17 ± 0.18C : 1.66 ± 0.35 → 1.53 ± 0.54IgA (p<0.05)T : 3.25 ± 0.56 → 2.24 ± 0.19C : 3.28 ± 0.27 → 3.17 ± 0.48Unstimulated salivary flow rate (p<0.05)T : 0.053 ± 0.057 → 0.154 ± 0.065C : 0.034 ± 0.116 → 0.078 ± 0.059 | No serious adverse reactions |
| Chen H18) (2020) | Radiation induced | T : 42C : 42 | T : Yangyin Qixiang Decoction + CC : Kangfuxin solution | 3 months | 1) Xerostomia score2) Stimulated salivary flow rate3) Parotid flow(PSV, EDV, RI, D) | Xerostomia score (p<0.05)T : 3.84 ± 0.31 → 2.23 ± 0.14C : 3.94 ± 0.16 → 3.31 ± 0.25Stimulated salivary flow rate (p<0.05)T : 0.25 ± 0.08 → 0.69 ± 0.18C : 0.23 ± 0.10 → 0.35 ± 0.14PSV (p<0.05)T : 28.658 ± 3.795 → 18.358 ± 4.108C : 29.145 ± 4.012 → 23.034 ± 3.984EDV (p<0.05)T : 9.789 ± 1.674 → 5.103 ± 1.452C : 9.981 ± 1.862 → 9.124 ± 1.112RI (p<0.05)T : 0.785 ± 0.148 → 0.613 ± 0.125C : 0.789 ± 0.674 → 0.695 ± 0.254D (p<0.05)T : 50.535 ± 0.715 → 17.186 ± 0.879C : 49.978 ± 0.491 → 48.352 ± 0.523 | NR |
| Zhou J19) (2020) | Radiation induced | T : 60C : 60 | T : Dongfang Shengjin Jiawei DecoctionC : None | 6 months | 1) TER2) Parotid flow(PSV, EDV, RI, D) | TER (p<0.05)T : 87%C : 53%PSV (p<0.05)T : 1.83 ± 0.21 → 3.86 ± 1.52C : 1.80 ± 0.23 → 1.78 ± 0.26EDV (p<0.05)T : 0.93 ± 0.20 → 1.23 ± 0.37C : 0.95 ± 0.18 → 0.93 ± 0.66RI (p<0.05)T : 1.98 ± 0.46 → 1.69 ± 0.22C : 2.01 ± 0.52 → 2.08 ± 0.61D (p<0.05)T : 4.92 ± 1.13 → 5.15 ± 0.69C : 4.83 ± 1.02 → 4.53 ± 1.21 | NR |
| Jia C20) (2021) | Sjogren’s syndrome | T : 29C : 28 | T : Runzao Jiedu liquid + hydroxychloroquineC : Hydroxychloroquine + normal saline gargle | 2 weeks | 1) Salivary flow rate2) VAS3) SF-364) TER5) TCM syndrome | Salivary flow rate (p<0.05)T : 1.03 ± 1.02 → 1.92 ± 0.95C : 0.90 ± 0.91 → 1.43 ± 0.85VAS (p<0.05)T : 6.00 ± 1.79 → 2.83 ± 1.49C : 5.68 ± 2.54 → 3.86 ± 1.94SF-36 (p<0.05): T > CTER (p<0.05)T : 96.55%C : 75.00%TCM syndrome (p<0.05): T < C | NR |
| Zhou T21) (2021) | Radiation induced | T : 39C : 41 | T : Sangshen soupC : Placebo | 3 weeks | 1) Xerostomia score2) Oral mucosal reaction3) NRS4) Occurrence time of xerostomia5) LASA quality of life score6) KPS score | Xerostomia score (p<0.05): T < COral mucosal reaction (p<0.05): T < CNRS (p<0.05): T < COccurrence time of xerostomia (p>0.05)T : 8.66 ± 3.80C : 8.75 ± 3.80LASA quality of life score (p<0.05): T > CKPS score (p<0.05): T > C | No serious adverse reactions |
| Chen X22) (2021) | Diabetic | T : 35C : 35 | T : TCM + auricular acupuncture + CC : Life intervention + insulin | 3 months | 1) Blood glucose compliance rate2) Glucose metabolism index3) TER | Blood glucose compliance rate (p<0.05)T : 91.43%C : 77.14%Pre-meal blood glucose (p<0.05)T : 9.0 ± 1.5 → 5.7 ± 0.8C : 9.1 ± 1.4 → 7.7 ± 1.22h postprandial blood glucose (p<0.05)T : 14.2 ± 2.4 → 7.7 ± 0.5C : 14.3 ± 2.2 → 10.2 ± 1.5Glycosylated hemoglobin value (p<0.05)T : 8.3 ± 1.0 → 5.8 ± 0.6C : 8.2 ± 0.8 → 7.5 ± 0.6TER (p<0.05)T : 94.29%C : 74.29% | NR |
| Huang A23) (2023) | Radiation induced | T : 30C : 30 | T : Modified Shashen Maidong Decoction + acupunctureC : Kangfuxin solution + sham acupuncture | 3 months | 1) Xerostomia score2) EF3) VAS4) TCM syndrome | Xerostomia score (p<0.05): T < CEF: T > CVAS (p<0.05): T < CTCM syndrome (p<0.05): T < C | NR |
| Sha S24) (2024) | Radiation induced | T : 40C : 40 | T : Qingre Lianyin DecoctionC : Lidocaine, dexamethasone and gentamicin mixed solution | 4 weeks | 1) Oral mucosal reaction2) Xerostomia score3) Salivary gland ultrasound score | Oral mucosal reaction (p<0.05): T < CXerostomia score (p<0.05): T < CSalivary gland ultrasound score (p<0.05): T < C | No serious adverse reactions |