| Son10) (2013) | Before and after study | 30 | Mean62.07 | 2.22 years | H-med(加味六味地黃湯, 加味淸心蓮子飮) + A-Tx (with electrical stimulation) + AIJ |
| Shim8) (2012) | Case series | 40 | Mean62.4 | 36.1 months | H-med(加味淸心湯, 安心溫膽湯, 淸血降氣散, 補血安神湯) |
| Yu15) (2023) | Case series | 32 | Mean66.34±6.50 | More than 3months | H-med(四逆湯加減, 理中湯加減) |
| Gao16) (2020) | RCT | Total 52TG : 30CG : 22 | TG Mean 48.55±1.74CG Mean 49.24±1.26 | - | TG : H-med + External use medicine(左金丸)CG : WM |
| Xie17) (2019) | RCT | Total 386TG : 193CG : 193 | TG Mean 58.2±6.67CG Mean 60.7±7.69 | TG (13.2±3.67)monthsCG (12.6±4.09)months | TG : H-med(增液湯 合 淸心蓮子飮) + WM + NB + PsychotherapyCG : WM + Gargle(Chlorhexidine) + Psychotherapy |
| Wan18) (2019) | RCT | Total 60TG : 30CG : 30 | TG Mean 51±2CG Mean 54±1 | TG (10.0±1.6)monthsCG (11.0±1.7)months | TG : A-Tx(with Tongue acupuncture)CG : WM + H-med(丹梔逍遙片) |
| Xiong19) (2018) | RCT | Total 110TG : 55CG : 55 | TG 32-68(54.36±3.65)CG 31-69(54.92±3.78) | TG 1-8(3.85±1.52)yearsCG 1-7(3.45±1.45)years | TG : H-med(滋陰降火湯 加減) + WMCG : WM |
| Hou20) (2020) | RCT | Total 48TG : 24CG : 24 | TG Mean 56.27±6.83CG Mean 58.32±8.92 | TG 7±2.32monthsCG 7±2.49months | TG : H-med(蔘苓白朮散 加減)CG : WM |
| Zhang21) (2018) | Case series | 60 | 38-78Mean : 56.74±5.43 | 1month-3yearsMean (11.58±2.27)months | A-Tx with Tongue acupuncture, Bloodletting) |
| Liu22) (2017) | RCT | Total 120TG : 60CG : 60 | TG Mean 50.02±3.25CG Mean 51.28±3.45 | TG (15.32±3.5)monthsCG (15.21±4.1)months | TG : H-med(小柴胡湯 加減)CG : WM |
| Zhang23) (2020) | RCT | Total 54TG : 27CG : 27 | TG 52-76(64.92±4.30)CG 51-75(65.18±3.95) | TG 1.1-4.9yearsCG 1.3-5.4years | TG : H-med(血府逐瘀湯 加減) + WMCG : WM |
| Ge24) (2020) | RCT | Total 155G1 : 50G2 : 50G3 : 55 | G1 54.86±13.37G2 50.96±11.02G3 52.95±12.92 | - | G1 : AA-TxG2 : WMG3 : AA-Tx + WM |
| Yang25) (2017) | Case series | 36 | 36-55 (n=27)56-63 (n=9) | 1month-3years | H-med |
| Chen26) (2004) | Case series | 34 | 45-65 | 1month-2years | H-med(知柏地黃湯 加減 / 生脈散 合 六味地黃湯 加減 / 四君子湯 合 逍遙散 加減) + Gargle(五倍子, 黃連, 烏梅) + Psychotherapy |
| Zhou27) (2012) | RCT | Total 42TG : 22CG : 20 | TG Mean 49±11.52CG Mean 50±13.43 | TG (5±4.32)yearsCG (5±4.59)years | TG : H-med(灼口湯)CG : WM |
| Yang28) (2011) | Case series | 33 | Under 40 (n=3)40-50 (n=21)50-60 (n=7)More than 60 (n=2) | 1month-2yearsMean 6months | H-med(龍膽瀉肝湯 加減 / 知栢地黃丸 加減 / 導赤散 加減) |
| Zhou29) (2009) | RCT | Total 62TG : 32CG : 30 | 26-70Mean 57±8 | 6months-16years | TG : H-med(導赤散 合 三黃湯 加減 / 十全大補湯 加減 / 龍膽瀉肝湯 加減 / 知栢地黃丸) + WMCG : WM |
| Peng30) (2019) | RCT | Total 60TG : 35CG : 25 | 45-65 | - | TG : H-med(左歸丸)CG : WM + NB |
| Hu31) (2016) | RCT | Total 96TG : 48CG : 48 | 35-75 | More than 3months | TG : H-med(雙花百合片)CG : H-med(一清胶囊, YIQING JIAONANG ;大黃,黃連,黃芩) |
| Zhao14) (2012) | Retrospective cohort study | Total 93TG : 63CG : 30 | - | - | H-med(左歸丸) |
| Li32) (2011) | RCT | Total 64TG : 32CG : 32 | TG 42-56(46.2±2.8)CG 43-58(46.5±3.2) | TG 4months-3.5yearsMean (1.3±0.7)yearsCG 0.5-4yearsMean (1.5±0.6)years | TG : H-med(柴芍颗粒)CG : WM |
| Guo33) (2009) | Case series | 80 | 35-75Mean 55±8 | 1-10years | H-med(引火歸元湯) |
| Huang34) (2007) | RCT | Total 120TG : 80CG : 40 | TG Mean 58.06±13.12CG Mean 59.25±13.27 | - | TG : H-med(連梅湯)CG : H-med(六味地黃丸) |
| Lou35) (2023) | RCT | Total 105TG : 50CG : 55 | TG 54.86CG 52.95 | - | TG : AA-TxCG : WM |
| Zhao36) (2020) | Case series | 867 | Mean 65.54±9.50 | - | H-med(逍遙散 加減) |
| Wang37) (2015) | Case series | 20 | 35-68Mean 52.5 | 2weeks-3yearsMean 8.1months | A-Tx(with Tongue acupuncture) |
| Sun38) (2011) | RCT | Total 80TG : 42CG : 38 | 33-70Mean 54.70±6.43 | 0.5-10.0yearsMean (18.4±5.6)months | TG : AA-Tx(with electrical stimulation)CG : WM |