| Zhang (2000) | 98(56:42) | T: 39/17C: 29/13 | NR | 真武汤2 times/d5ds/wk8wk | Terfenadine 60㎎2 times/d8wk | 1. Curative effect1) 痊愈: No more wheals in cold environment, 1 year later wheal does not appear in cold environment.2) 有效: No more wheals in cold environment, 1 year later wheals can appear in cold environment.3) 无效: Discontinuation of medication immediately causes skin lesions. | 1. Curative effect N(%)(痊愈/有效/无效)T: 32(57%)/16(29%)/8(14%)C: 0(0%)/11(26%)/31(74%) | NR |
| T: 24-52C: 28-49 |
| Wang (2004) | 60(30:30) | NR | NR | 加味麻黄汤2 times/d2wk | Cyproheptadine 2㎎, Cimetidine 200㎎, Vit E 100㎎3 times/d2wk | 1. TER*总有效率=痊愈+显效+有效1) 痊愈: All skin lesions subside and subjective symptoms disappear. Cold irritation does not cause skin lesions.2) 显效: Skin lesions subside by more than 60% and subjective symptoms decrease. Cold irritation can cause skin lesions.3) 有效: Skin lesions subside by 30-60% and subjective symptoms decrease. Cold irritation can cause skin lesions immediately.4) 无效: Skin lesions subside by less than 30% and subjective symptoms does not decrease. Cold irritation still cause skin lesions. | 1. TER N(%)T: 28(93.33%) > C: 21(70.00%)§ | T: mild gastric discomfort(2)C: sleepiness(12) |
| NR |
| Yu (2008) | 90(52:38) | T: 23/29C: 17/21T: 18-67(24.75±5.70)C: 16-68(22.76±5.39) | T: 2m-3y(8.75±0.93m)C: 2m-4y(10.26±0.34m) | 桂枝汤加减2 times/d2wk | Cetirizine HCl 10㎎1 time/d2wk | 1. Symptom score1) Itching: 0-32) Number of wheals: 0-33) Size of wheals: 0-34) Frequency of symptom: 0-32. TSS3. TER*总有效率=基本治愈+显效1) 基本治愈: TSSRI≥90%2) 显效: 60%≤TSSRI≤89%3) 进步: 20%≤TSSRI≤59%4) 无效: TSSRI<20% | 1. Symptom score1) ItchingT: 0.81±1.02 < C: 2.01±0.31§§2) Number of whealsT: 0.83±1.21 < C: 2.09±0.28§§3) Size of whealsT: 0.69±0.35 < C: 2.01±0.17§§4) Frequency of symptomT: 0.75±0.26 < C: 1.98±0.13§§2. TSST: 3.12±0.14 < C: 7.12±0.54§§3. TER N(%)1) 7 days after treatmentT: 36(69.2%) > C: 16(42.1%)§2) 14 days after treatmentT: 46(88.5%) > C: 18(47.4%)§§ | T: noneC: mild fatigue(5), mild dizziness(3), mild drowsiness(2) |
| Xu (2008) | 126(66:60) | T: 15/51C: 12/48 | T: 3m-6y(2.3y)C: 3m-7y(2.5y) | 祛风散寒汤1剂/d60d | Cetirizine10㎎1 time/d60d | 1. TSS1) Itching: 0-32) Size of wheals: 0-33) Number of wheals: 0-32. TER*总有效率=痊愈+显效1) 痊愈: TSSRI≥90%2) 显效: 60%≤TSSRI<90%3) 有效: 20%≤TSSRI<60%4) 无效: TSSRI<20% | 1. TSST: 2.01±0.05 < C: 4.97±1.01§2. TER N(%)T: 61(92.4%) > C: 42(70.0%)§ | NR |
| T: 17-62(32.1)C: 16-60(31.9) |
| Li (2010) | 81(49:32) | T: 28/21C: 19/13 | T: 3m-6yC: 3m-4.8y | 升阳益胃汤加减2 times/d30d | Ebastine 10㎎(20㎎ for severe cases)1 time/d30d | 1. TSS2. TER*总有效率=痊愈+显效*TSS change rate: (pre treatment TSS - post treatment TSS)/pre treatment TSS1) 痊愈: TSS change rate≥0.92) 显效: 0.6≤TSS change rate<0.93) 好转: 0.2≤TSS change rate<0.64) 无效: TSS change rate<0.23. Relapse rate(After 3m) | 1. TSST: 2.13±1.47 < C: 5.64±2.26§2. TER N(%)T: 46(93.9%) > C: 24(75.0%)§§3. Relapse rate(After 3m) N(%)T: 3(10.3%) < C: 7(63.6%)§§ | T: noneC: 2(drowsiness, incapacity)*This did not affect daily life and work, and symptoms disappeared after stopping the medication. |
| T: 13-59(30.3)C: 14-58(32.8) |
| Li (2011) | 92(48:44) | T: 22/26C: 20/24 | T: 3m-6.5y(3.1±1.13y)C: 2.5m-6.0y(2.8±1.24y) | 麻桂各半汤加味2 times/d20d | Mizolastine 10㎎1 time/d20d | 1. TSS1) Itching: 0-32) Number of wheals: 0-33) Symptom duration: 0-34) Size of wheals: 0-35) Frequency of symptom: 0-36) Ice test: 0-32. TER*总有效率=痊愈+显效+有效*TSS change rate: (pre treatment TSS - post treatment TSS)/pre treatment TSS1) 痊愈: TSS change rate≥0.92) 显效: 0.6≤TSS change rate<0.93) 有效: 0.2≤TSS change rate<0.64) 无效: TSS change rate<0.23. Relapse rate(After 3m) | 1. TSST: 3.42±3.27 < C: 6.22±4.54§§2. TER N(%)T: 23(93.75%) > C: 30(72.72%)§§3. Relapse rate(After 3m) N(%)T: 2(4.17%) < C: 6(13.64%)§§ | T: noneC: 8(dizziness, drowsiness, incapacity)*This did not affect daily life and work, and symptoms disappeared after stopping the medication. |
| T: 18-69(37.3±8.2)C: 18-69(34.8±7.6) |
| Xie (2011) | 62(31:31) | T: 14/17C: 13/18 | NR | 温经活血汤3 times/d6wk | Mizolastine 10㎎1 time/d6wk | 1. TER*总有效率＝痊愈＋显效＋有效1) 痊愈: TSSRI≥90%2) 显效: 60%≤TSSRI<90%3) 有效: 30%≤TSSRI<60%4) 无效: TSSRI<30% | 1. TER N(%)T: 26(83.87%) > C: 20(64.52%)§ | NR |
| T: 18-67(33.74±8.57)C: 18-65(34.12±7.84) |
| Li (2012) | 68(37:31) | T: 21/16C: 17/14 | T: 6m-3.5y(2.1±1.24y)C: 6m-4y(1.94±0.93y) | 芪桂祛风汤2 times/d4wk | Mizolastine 10㎎1 time/d4wk | 1. TER*总有效率＝痊愈＋显效*Symptom score: Itching, size of wheals, number of wheals each 0-3 points1) 痊愈: TSSRI≥90%2) 显效: 60%≤TSSRI<90%3) 好转: 20%≤TSSRI<60%4) 无效: TSSRI<20% | 1. TER N(%)1) After treatmentT: 29(78.38%) > C: 20(64.52%)§2) Follow-up in 2 monthsT: 24(64.86%) > C: 12(38.71%)§ | NR |
| T: 19-55(35.76±10.81)C: 19-53(32.87±8.06) |
| Liu (2015) | 68(34:34) | T: 18/16C: 15/19 | T: 7d-3yC: 7d-3y | 桂附理中汤加味1 time/d1-2wk | Loratadine 10㎎(5㎎ for children under 12 years old)1 time/d1-2wk | 1. TER*总有效率=痊愈+显效+有效1) 痊愈: Contact with ice or cold water(i.e. ice test), no wheals and no itching.2) 显效: Contact with ice or cold water(i.e. ice test), no wheals and mild itching.3) 有效: Contact with ice or cold water(i.e. ice test), a small amount of wheals and mild itching.4) 无效: Contact with ice or cold water(i.e. ice test), no wheals and itching disappear. | 1. TER N(%)T: 33(97.1%) > C: 26(76.5%)§ | NR |
| T: 10-55C: 10-55 |
| Zhao (2015) | 180(90:90) | T: 48/42C: 41/49 | NR | 玉屏桂枝乌梅汤2 times/d*If the skin symptoms disappear, take it every day for a week, and take it every other day for two weeks, and if the symptoms recur, take it again every day, and if they do not recur, stop taking it. | Cetirizine HCL 10㎖1 time/d*If the skin symptoms disappear, take it every day for a week, and take it every other day for two weeks, and if the symptoms recur, take it again every day, and if they do not recur, stop taking it. | 1. TER*总有效率=治愈+显效+有效1) 治愈: The wheals and symptoms disappear and do not recur.2) 显效: The wheals disappear more than 75% and itching and other symptoms are significantly reduced.3) 有效: 30% of the wheals subsides, or the recurrence interval is prolonged after subsiding, itching and other symptoms are relieved.4) 无效: The wheals or itching did not improve significantly, or less than 30%.*The evaluation was carried out 1m after discontinuation of medication. | 1. TER N(%)T: 82(91.11%) > C: 32(35.56%)§ | NR |
| T: 5-45(30±8.8)C: 6-43(31±9.2) |
| Wang (2017) | 72(36:36) | NR | NR | 玉桂宁荨汤2 times/d4wk | Mizolastine 10㎎1 time/d4wk | 1. Symptom score1) Itching: 0-32) Number of wheals: 0-33) Size of wheals: 0-34) Frequency of symptom: 0-32. TER*总有效率=痊愈+显效1) 痊愈: TSSRI≥90%2) 显效: 60%≤TSSRI<90%3) 有效: 30%≤TSSRI<60%4) 无效: TSSRI<30%3. Relapse rate4. IL-6, IL-8, IFN-γ | 1. Symptom score1) ItchingT: 1.01±0.82 < C: 1.46±0.13§2) Number of wheals§T: 1.12±0.35 < C: 1.89±0.80§3) Size of whealsT: 1.05±0.37 < C: 1.79±0.82§4) Frequency of symptomT: 1.37±0.78 < C: 1.68±0.88§2. TER N(%)T: 26(72.22%) > C: 16(44.44%)§3. Relapse rate N(%)T: 3(11.53%) < C: 11(68.75%)§4. IL-6, IL-8, IFN-γ(ng/㎖)1) IL-6T: 3.58±2.46 < C: 6.87±3.66§2) IL-8T: 3.96±2.93< C: 2.31±1.78§3) IFN-γT: 25.19±3.71 > C: 19.83±4.79§ | NR |
| NR |
| Cheng (2018) | 70(35:35) | T: 16/19C: 17/18 | T: 1-24m(17.48±12.08m)C: 1-24m(18.18±11.78m) | 加味当归四逆汤2 times/d1wk | Cetirizine HCL 10㎎2 times/d1wk | 1. TSS1) Number of wheals: 0-32) Itching: 0-32. TER*总有效率=痊愈+显效+有效1) 痊愈: TSSRI≥90%2) 显效: 60%≤TSSRI<90%3) 有效: 20%≤TSSRI<60%4) 无效: TSSRI<20% | 1. TSST: 1.65±0.41 < C: 1.87±0.45§2. TER N(%)T: 34(97.1%) > C: 25(71.4%)§ | NR |
| T: 18-60(37.48±12.08)C: 18-60(38.14±11.97) |