Table 1. Characteristics of Clinical Studies of Sound Therapy on Tinnitus

First author (year) Treatment intervention(n) Control intervention 1(n) Control intervention 2(n) Control intervention 3(n) Volume of the sound source Implement Duration of treatment
Tong14) (2022) TMNMT(60)- Notch-filtered music was made automatically by the software based on the characteristics of patient’s tinnitus. TRT(60)- Sound therapy + counselling (40-60 min/session)- Broad band nature sound : wind, rain, waves - - - TMNMT : Comfortable loudness(75-80dB) Mobile platform of music therapist software 2 hrs/day daily for 3 months
- TRT : Mixing point
Jin9) (2022) Sound therapy 1 hr/day(20) Sound therapy 3 hrs/day(20) Sound therapy 5 hrs/day(20) - Mixing point APP 1,3,5 hrs/day daily for 3 months
BBN(white noise, 100-22,050㎐)
Hall3) (2022) ACRN(50)- ± Two tones of the matched tinnitus pitch. Tones were presented randomly at a cycle repitition rate of 1.5㎐. Placebo(50)- Four tone stimulation included frequencies in 500-4000㎐ only at a cycle repetition rate of 0.3㎐, but the tinnitus frequency region was excluded. - - Soft but audible listening level T30 neuro-stimulator 4-6 hrs/day daily for 12 weeks
Formby10) (2022) TRT(51)- Sound therapy + counselling- BBN(continuous, low-level) pTRT(51)- Placebo sound therapy + counselling- BBN below mixing point for the first 40 min of operation, after which the placebo out put began a gradual decay process to silence over the next 30 min of use. SoC(49)- Counselling - Mixing point Ear-worn SG 18 months
Mondelli15) (2021) White noise(9) Pink noise(9) Speech noise(9) High tone(9) Lowest intensity capable of promoting some tinnitus relief Hearing aids with SG 3 months
Li16) (2021) Observational group(46)- Pure tone ST with 7 octaves (0.125, 0.25, 0.5, 1, 2, 4, 8) Control group(46)- Pure tone ST with 9 one-third octaves - - Therapeutic sounds were heard while tinnitus was just absent. NR 30 min/session3 sessions/day 3 months
+ Gaussian noise (noise at a frequency of tinnitus frequency ± 2Kz) + psychological intervention
Jin11) (2021) Non-notched noise(14)- BBN(white noise, 100-22,050㎐) Notched noise(16)- Notched BBN, applied a band-reject filter with an ½-octave bandwidth centered at the tinnitus frequency. Mixing point APP 3 hrs/day daily for 12 months
Jeong19) (2020) Air-conduction transducer(10) Bone-conduction transducer(10) - - Mixing point Sound file stored on patient's phone ≥ 3 hrs/day daily for 3 months
BBN(44,100㎐ ampling rate, 32bit)
Yoo (2020)18) BBN(20) Nature sound(20)- Running water Music sound(18)- Vivaldi's 'The four seasons, spring' - Mixing point APP 3 hrs/day daily for 3 months
Jeong12) (2019) TRT using Nature sounds(12)- Sound therapy + counselling(4 sessions)- Nature sound : Waves, water of stream TRT using BBN(7)- Sound therapy + counselling(4 sessions) Partial masking Sound file stored on patient's phone ≥ 3 hrs/day daily for 3 months
Scherer13) (2019) TRT(51)- TC(counseling)+ ST(low-level BBN therapy using SG) Partial TRT(51)- TC + placebo ST- Operation of SG during the first 40 min was identical, after which the placebo output was attenuated at a rate of 1dB per min SoC(49)- Standard of care Just below the point at which the tinnitus and SG noise blended SG ≥ 8 hrs/day daily for 18 months
Munro20) (2019) Binaural beats(10)- Lt.400㎐, Rt.408㎐ with a binaural beat frequency of 8㎐(alpha frequency) + overlay of ocean waves Ocean waves without alpha frequency(8㎐)(10)- Same ocean waves but without the binaural beat source frequencies. 20dB SL above their threshold MP3 player 10 min/session 1 session
Li17) (2019) BBN(14)- Gaussian noise (noise at a frequency of tinnitus frequency ± 2Kz) The mixed pure tones + BBN(14)- BBN + mixed pure tones of nine different frequencies Total masking Sound file stored on patient's phone 30 min/session3 sessions/day3 months
Aydin21) (2019) BBN(10) Nature sound(11)- Self-selected nature sound (ocean waves, stream, rain or shower sounds) Comfortable loudness APP 30 min/session1 session
TMNMT: Tailor-Made Notched Music Training, TRT: Tinnitus Retraining Therapy, ACRN: Acoustic Coordinated Reset(CR®) Neuromodulation, ST: Sound Therapy, NR: Not Reported, BBN: Broad Band Noise, SG: Sound Generator, APP: Application