Appendix 1. Drugs Recommended for Meniere's Disease in Guidelines and Their Target Proteins

No.	Drugs	Target proteins	No.	Drugs	Target proteins
1	acetazolamide	CA2	84	eplerenone	TIMP2
2	acetazolamide	CA1	85	ethacrynic acid	GSTP1
3	acetazolamide	CA4	86	ethacrynic acid	GSTA1
4	acetazolamide	CA9	87	ethacrynic acid	SLC12A1
5	acetazolamide	CA7	88	ethacrynic acid	REN
6	acetazolamide	CA12	89	ethacrynic acid	CLEC3B
7	acetazolamide	CA14	90	ethacrynic acid	TARDBP
8	acetazolamide	CA3	91	ethacrynic acid	ATP1A1
9	acetazolamide	AQP1	92	ethacrynic acid	EMP1
10	acetazolamide	CA5A	93	ethacrynic acid	ABCC1
11	amiloride	PLAU	94	ethacrynic acid	AKR1C2
12	amiloride	SCNN1A	95	furosemide	ALB
13	amiloride	REN	96	furosemide	REN
14	amiloride	ASIC2	97	furosemide	SLC12A2
15	amiloride	SLC9A1	98	furosemide	SLC12A1
16	amiloride	SCNN1G	99	furosemide	SLC12A4
17	amiloride	SCNN1B	100	furosemide	SERPINE1
18	amiloride	ASIC1	101	furosemide	BSND
19	amiloride	SCNN1D	102	furosemide	CA2
20	amiloride	SLC9A2	103	furosemide	AVP
21	bendrofluazide	REN	104	furosemide	SLC12A5
22	bendrofluazide	SLC12A3	105	hydrochlorothiazide	ACE
23	bendrofluazide	SLC12A1	106	hydrochlorothiazide	CA2
24	bendrofluazide	CA1	107	hydrochlorothiazide	SLC12A1
25	bendrofluazide	CA4	108	hydrochlorothiazide	REN
26	bendrofluazide	KCNMA1	109	hydrochlorothiazide	AQP2
27	bendrofluazide	CA2	110	hydrochlorothiazide	SLC12A3
28	bendrofluazide	TPMT	111	hydrochlorothiazide	CA1
29	betahistine	HRH1	112	hydrochlorothiazide	CA9
30	betahistine	HRH3	113	hydrochlorothiazide	CA12
31	betahistine	HRH2	114	hydrochlorothiazide	SERPINE1
32	brinzolamide	CA2	115	indapamide	KCNE1
33	brinzolamide	CA4	116	indapamide	CA2
34	brinzolamide	CA1	117	indapamide	CA7
35	brinzolamide	CA5A	118	indapamide	REN
36	brinzolamide	CA6	119	indapamide	KCNQ1
37	brinzolamide	CA7	120	indapamide	VEGFA
38	brinzolamide	CA13	121	indapamide	CA12
39	brinzolamide	CA12	122	isosorbide	BCL2
40	brinzolamide	CA14	123	isosorbide	MCL1
41	brinzolamide	CA9	124	isosorbide	BCL2L1
42	bumetanide	SLC12A2	125	methazolamide	CA1
43	bumetanide	SLC12A1	126	methazolamide	CA9
44	bumetanide	CFTR	127	methazolamide	CA2
45	bumetanide	REN	128	methazolamide	CA4
46	bumetanide	SLC12A5	129	methazolamide	CA7
47	bumetanide	EDN1	130	methazolamide	CA3
48	bumetanide	SLC12A4	131	methazolamide	CA6
49	bumetanide	TSC1	132	methazolamide	CA12
50	bumetanide	SLC32A1	133	methazolamide	CA5A
51	bumetanide	CALB1	134	methazolamide	CA13
52	chlorthalidone	CA2	135	methyclothiazide	CA1
53	chlorthalidone	CA7	136	methyclothiazide	SLC12A1
54	chlorthalidone	REN	137	methyclothiazide	CA2
55	chlorthalidone	CA12	138	methyclothiazide	CA4
56	chlorthalidone	CA5B	139	spironolactone	NR3C2
57	chlorthalidone	SLC12A1	140	spironolactone	GPER
58	chlorthalidone	CA9	141	spironolactone	AR
59	dichlorphenamide	CA2	142	spironolactone	REN
60	dichlorphenamide	CA7	143	spironolactone	ALB
61	dichlorphenamide	CA1	144	spironolactone	ACE
62	dichlorphenamide	CA4	145	spironolactone	NR3C1
63	dichlorphenamide	CA9	146	spironolactone	PGR
64	dichlorphenamide	CA6	147	spironolactone	ENSG00000264813
65	dichlorphenamide	CA5A	148	spironolactone	SERPINE1
66	dorzolamide	CA2	149	thiazide	REN
67	dorzolamide	CA4	150	thiazide	SLC12A3
68	dorzolamide	CA1	151	thiazide	CA2
69	dorzolamide	CA7	152	thiazide	CA1
70	dorzolamide	CA12	153	thiazide	NOS1
71	dorzolamide	CA6	154	thiazide	CA4
72	dorzolamide	CA9	155	thiazide	CALB1
73	dorzolamide	CA5A	156	torasemide	REN
74	dorzolamide	CA14	157	torasemide	TBXA2R
75	eplerenone	NR3C2	158	torasemide	CYP2C9
76	eplerenone	REN	159	torasemide	CYP2C8
77	eplerenone	GPER	160	torasemide	SLC12A1
78	eplerenone	GPX1	161	triamterene	SCNN1A
79	eplerenone	NOS3	162	triamterene	SCNN1B
80	eplerenone	ADIPOQ	163	triamterene	SCNN1D
81	eplerenone	CYP3A4	164	triamterene	SCNN1G
82	eplerenone	CYP3A7	165	triamterene	HIF1A
83	eplerenone	NCF4	166	triamterene	CYP1A2