Appendix 2. The Information of Compounds and Target Protein Ranking by Degree

No.	Compounds	Degree	No.	Target poteins	Degree
1	naringenin	22	1	CASP3	9
2	beta-sitosterol	16	2	CYP1B1	5
3	Stigmasterol	16	3	CYP1A2	4
4	baicalein	11	4	ABCG5	4
5	baicalin	11	5	ABCG8	4
6	calycosin	11	6	ICAM1	4
7	dihydrocapsaicin	11	7	UGT1A8	4
8	formononetin	11	8	CYP1A1	4
9	glabridin	11	9	AKT1	3
10	isorhamnetin	11	10	UGT1A1	3
11	kaempferol	11	11	UGT1A10	3
12	mairin	11	12	UGT1A3	3
13	quercetin	11	13	UGT1A7	3
14	sitosterol	11	14	UGT1A9	3
15	nobiletin	11	15	HMOX1	3
			16	IL8	3
			17	NOTCH2	2
			18	ESR2	2
			19	CYP3A4	2
			20	MMP2	2
			21	MMP9	2
			22	MYC	2
			23	VEGFA	2
			24	ABCB11	2
			25	APOE	2
			26	CASP9	2
			27	CYP7A1	2
			28	DHCR24	2
			29	SREBF1	2
			30	SREBF2	2
			31	MAPK3	2
			32	UGT2B7	2
			33	TYR	2
			34	ABCC1	2
			35	ABCB1	2
			36	APOB	2
			37	BDNF	2
			38	CCL2	2
			39	LDLR	2
			40	PPARA	2
			41	RAPGEF1	2
			42	ABCA1	2
			43	IL10	2
			44	SLCO1B1	2
			45	TNF	2