Table 2. TGF-β1, Hyaluronan and COL1 Synthetic Gene – HAS1, HAS2, HAS3, COL1A1 and COL1A2 mRNA Expressions in Dorsal Back Skin Tissues

Target genes	mRNA expressions on the dorsal back skin tissues
Groups	HAS1	HAS2	HAS3	COL1A1	COL1A2	TGF-β1
Controls
Intact vehicle	1.00±0.06	1.00±0.10	1.00±0.04	1.00±0.06	1.00±0.05	1.00±0.06
L-AA
100㎎/㎏	1.67±0.21^a	1.64±0.22^a	1.55±0.19^a	1.76±0.25^a	1.69±0.24^a	1.71±0.17^a
UA
400㎎/㎏	2.07±0.43^a	2.06±0.42^a	1.97±0.42^a	2.27±0.34^a	2.15±0.29^a	1.91±0.27^a
200㎎/㎏	1.68±0.19^a	1.67±0.21^a	1.55±0.21^a	1.77±0.21^a	1.69±0.20^a	1.69±0.14^a
100㎎/㎏	1.38±0.15^a	1.37±0.16^a	1.31±0.15^a	1.49±0.20^a	1.42±0.21^a	1.50±0.23^a

Results are expressed mean±SD of 10 mice, relative to control/β-actin
p<0.01, as compared with intact vehicle control
L-AA, L-Ascorbic acid, reference drug; UA, Unripe apple(Immature fruit of Malus pumila Mill); COL1A, Collagen, type I, alpha; HAS, Hyaluronan synthase; TGF, Transforming growth factor.