| Yu WX24) (2019) | 1, 2, 3, 4w | NR | 1)Wound flora inhibition↑#2)Wound area↓#3)High-sensitivity C-reactive protein↓# | NR | Jiazhu Huanglian oint combined with basal debriment is superior to single-use debriment treatment in DF patients with moderate to severe infection. |
| Wang HY25) (2019) | 4w | CE(%) 95.24:83.33(p<0.05) | TCM syndrome scores↓# | NR | Quanxie oint is better than silver ion dressing in the treatment of DFU |
| Qie FH26) (2019) | NR | UH-100%(%) 30:20(p>0.05) | 1)Time until granulation tissue is formed↓#2)Time to epithelialization↓#3)Healing time↓# | NR | Poppy oint can significantly shorten the time of granulation tissue growth, epithelialization and the time of healing. |
| Haung ZF27) (2018) | 4, 8, 12, 16w | UH-100%(4w, f) 0/48:0/48UH-100%(8w, f) 3/48:1/48UH-100%(12w, f) 32/48:28:48UH-100%(16w, f) 45/48:47/48 | 1)Healing time↓2)VAS↓# | NR | Jingwanhong ointment and nano-silver gel both have the effect of promoting the healing of chronic wounds of DF. But Jinwanhong ointment is more comfortable and more release pain. |
| Chen C28) (2018) | 1m | CE(%) 92.16:78.43(p<0.05) | 1)Level of VEGF↑#2)Level of expression of PDGFR-α in granulation tissues↑# | No severe AE(pain, numbness, skin darkening, liver, kidney damage)4.90:5.88(%) | Shengji yuhong ointment can effectively increase the expression of PDGFR-α, improve clinical efficacy, and high clinical application value in the treatment of DFU. |
| Wang Z29) (2015) | 1m | CE(%) 97.0:72(p<0.01) | 1)Dorsal foot artery blood flow velocity and superficial peroneal nerve sensory conduction velocity↑#2)Cost of the treatment↓#3)Treatment peroid↓#4)Amputation rate↓# | NR | Shengji Yupi ointment in DF can significantly improve the blood flow velocity of the dorsal foot artery and the sensory conduction velocity of the superficial peroneal nerve, and promote wound healing, improving curative effect, has high clinical value. |
| Wang ZB30) (2015) | 3w | NR | 1)Area of ulcer↓# | NR | Shengjiyupi ointment has better clinical effect than conventional medicine in treating DFU. |
| Zhao ZF31) (2015) | 12w | CE(%) 95.0:57.5(p<0.05)UH-100%(f) 29/40:12/40 | 1)NRS↓#2)Area of ulcer↓# | NR | Liqi ointment combined with baikerui gauze wet compress has a significant effect on the treatment of grade 2-4 DFU, and it is safe, effective, and convenient treatment method. |
| Li JP32) (2015) | 4w | CE(%) 70.00:67.00(p>0.05) | Symptoms and signs scores↑# | NR | Babao shengji ointment is effective in the treatment of DF. |
| Jiang YF33) (2015) | 2, 5, 10, 15, 20w | NR | 1)Area of ulcer↓#2)Healing time↓# | NR | Both Jingwanhong ointment and compound of sulfadiazine zinc cream could promote healing of DFU, and the effect of Jinwanhong ointment is superior. |
| Wang J34) (2014) | 28d | CE(%) 96.875:84.375(p<0.05) | None | NR | Quanxie ointment with MEBO has better curative effect on DF than Silver ion gauze dressing. |
| Cao BL35) (2014) | 0, 10, 20, 30d | CE(%) 95.23 : 63.15(p<0.05) | Area of ulcer↓# | No severe AE (mild skin itching) | The traditional chinese medicine ointment can promote the wound healing of DFU. |
| Long CX36) (2014) | 40d | CE(%) : 96.6:73.4(p<0.05) | 1)Time until granulation tissue is formed↓#2)Time to epithelialization↓#3)Healing time↓# | NR | Ma yinglong hemorrhoid ointment combined with Yunnan baiyao applied to DFU has the function of promoting wound healing, improving the quality of wound healing and shortening the healing time of wounds . |
| Zhu XJ37) (2013) | 0, 10, 20d | CE(%) : 92.9:71.4(p<0.05) | 1)Time until granulation tissue is formed ↓#2)Healing time↓# | None | Shengji yuhong ointment for the treatment of DF(damp-heat and posionous type) has clinical effection without obvious adverse reactions. |
| Wang A38) (2012) | 30d | CE(%) : 96.67:76.67(p<0.05)UH-100%(%) 56.67:36.67(p<0.05) | Healing time↓# | None | Shisiweilianhuang burn ointment can improve the cure rate and total effective rate of DFU treatment, and can shorten the time. |
| Gao GY13) (2012) | 30d | CE(%) 96.67:66.67(p<0.01) | None | NR | Huofu ointment is effective in treating DF. |
| Li SF39) (2011) | 0, 4, 12, 24w | CE(%)12w 79.2:41.7(p<0.05)24w 91.7:62.5(p<0.05) | Healing time↓ | AE 8/8Serious AE 4/2Death 3/2UGB1/0Study-related AE 4/6Discontinued due to AE 4/3amputation4/4reoccurrence1/1 | Tangzu Yuyang Ointment is more effective than conventional treatment in the management of chronic DFU and has few side-effects |
| Su DB40) (2010) | 30, 60d | CE(%) 96.67 : 93.33(p<0.05)30d UT-100%(%) 86.67:50.00(p<0.05)60d UT-100%(%) 93.33:66.67(p<0.05) | None | None | External application of chinese medicine(SM oint) has a good effect on DFU. |
| Yuan XM41) (2009) | 60d | CE(%) 93.4:78.6(p<0.05)UT-100%(%) 56.7:39.3(p<0.05) | Area of ulcer↓# | NR | Ointment for clearing heat, detoxifying and removing dampness combined with topical antibiotics in the treatment of DFU is more effective than antibiotics alone. |
| Fu LJ42) (2006) | 60d | CE(%) 89.24:68.18(p<0.05) | None | None | Xiangpi shengji ointment can accelerate wound healing and increase cure rate of DFU. |