Table 4. Treatment Schemes of the Included Studies

Author (year) Internal therapy (Common treatment) Wound care (Common in both group) Treatment period Duration
Wound care in the treatment group Wound care in the control group
Yu WX24) (2019) · Control BS, BP, LP(;statin), IF· Prevent PA(;aspirin)· Correct hypoproteinemia · Irrigation(NS), drainage, debriment 1/d 4w
Jiazhu Huanglian oint(5-10㎝ wide)+sterile gauze Rivanol gauze(;ethacridine lactate(雷夫诺尔溶液))
Wang HY25) (2019) · Control BS, LP, IF· Health care education(;diet) · Debriment· Sterilze gauze, bandage 1/d 4w
Quanxie oint (1-2㎜ tk)+ointment soaked gauze Silver ion ointment(1-2㎜ tk)+silver ion soaked gauze
Qie FH26) (2019) · Control IF· Improve BC · Debriment 2/d NR
Poppy oint(1-2㎜ thick (wound) + congested area)+sinus/abscess cavity were soaked with gauze strips*daily dose <10g Irrigation(0.9 sodium chloride solution)+sinus/abscess cavity were soaked with liquid guaze(5% povidone-iodine, 0.9 sodium chloride solution)
Haung ZF27) (2018) · Control BS, BP, LP· Health care education(;diet, smoking) · Irrigation(NS), disinfection(0.9 sodium chloride solution) 1/2d 16w
Jin Wanhong oint(3㎜ tk) Sulfadiazine zinc gels(3㎜ tk)
Chen C28) (2018) · Control BS, BP, LP, IF· Health care education(;diet, exercise) · Irrigation(NS), disinfection(hydrogen peroxide), debriment· DF sol(soaked gauze :insulin inj.(12U), gentamycin inj.(16U), anisodamine inj.(10㎎), 250㎖ of NS) 1/d 1m
DF sol soaked guaze for 10m, and then remove+shengji Yuhong oint(thickness that covers all wounds) DF sol soaked gauze
Wang Z29) (2015) · Control BS(;insulin)· Health care education(;diet) · Irrigation, debriment C:1/dT:1/1-3d 1m
Shengji Yupi oint(2㎜ tk) Benzyldodecyldimethylammonium Bromide (;0.1% 新洁尔灭)
Wang ZB30) (2015) · Control BS, IF· Improve BC(;alprostadil)· Health care education(;diet) · Disinfection(;新洁尔灭=Benzyldodecyldimethylammonium Bromide)· Microwave0.5h 1/1-3d 3w
Shengji Yupi oint(2㎜ tk) Insulin+黄芪、丹参 external use
Zhao ZF31) (2015) · Control BS, IF· Nerve nutrition,· Improve BC· Health care education(;diet, foot care, psychological care) · Disinfection(iodophor), irrigation(NS), debriment· Bactericide soaked gauze(;百克瑞)· Sterilze gauze 1/1-3d 12w
Liqi ointment(1-2㎜ tk) CT
Li JP32) (2015) · Control BS · Irrigation, disinfection, debriment T:1/2dC:1/d 4w
Babao shengji oint Bactericide soaked gauze(;百克瑞), sterilze gauze
Jiang YF33) (2015) NR · Irrigation(NS)· Sterilize gauze 1/2d 20w
Jingwanhong oint(3㎜ tk) Sulfadiazine zinc gel
Wang J34) (2014) · Control Control BS, BP, LP, IF· Nerve nutrition· Improve BC · Irrigation, debriment· Sterilize gauze, bandage 1/d 28d
Quanxie oint + MEBO Silver ion gauze
Cao BL35) (2014) · Control BS· Nerve nutrition· Micro circulation improving· Health care education(;diet; spicy food) · Disinfection 1/d 30d
Among the three oints, choose according to the condition of the ulcer 0.1 ethacridine lactate sol(;雷夫诺尔溶液))
Long CX36) (2014) · Control BS, IF Irrigation(;NS), disinfection(;3% hydrogen peroxide sol), elastic bandage 1/d 40d
Mayinglong hemorrhoid ointment+Yunnan Baiyao (1:1) 10% povidone-iodine oint
Zhu XJ37) (2013) · Control BS(;insulin, oral hypoglycemic drugs), BP, LP, IF· Health care education(;diet-no greasy food/alcohol, exercise)· Improve BC(;alprostadil,salvia)· Check the arteries of the dorsal foot· Correct hypoproteinemia, electrolyte disorder, acid-base balance disorders, anemia ·Irrigation(NS), disinfection(3% hydorgen peroxide sol), debriment· Sterilize gauze 1/d(for 10d)1/2d(for 10d) 20d
Shengji Yuhong oint soaked guaze CT
Wang A38) (2012) · Control BS, LP, IF · Disinfection(;hydrogen peroxide, iodophor), irrigation(NS)· Sterilize gauze, bandage 1/1-2d 30d
Shisiweilianhuang burn oint Vaseline gauze
Gao GY13) (2012) · Control BS(;insulin), LP· Prevent PA· Health care education(;diet)· Improve BC(;oral medicine Tongxinluo Capsules) · Irrigation(NS), disinfection(;3% hydorgen peroxide sol), debriment· Sterilize guaze 1/2d 30d
Huofu oint(Coin-thick, wider than the wound) · Vaseline gauze· Iodophor soaked gauze (cavity, if nessasary)
Li SF39) (2011) · Control BS, BP, LP, IF(;only oral)· Health care education(;off loading) · Irrigation(NS), debriment 1/1-3d Until wound healing
oint (1㎜ tk) CT
Su DB40) (2010) · Control BS, IF· Prevent PA· Health care education(;diet, foot care) · Irrigation(NS), disinfection, debriment 1-2/d 60d
SM1 oint:dark/yellow phasesSM2 oint:granulation, epithelialization phase 654-2 insulin, gentamycin soaked gauze
Yuan XM41) (2009) · Control BS(;Insulin), BP, LP, IF(;oral)· Improve BC(;脉络宁注射液, 胰激肽原酶等静脉滴注)· Prevent PG(;Aspirin)· Nutrition supply(;Methylcobalamin)· Health care education(;diet) · Irrigation(NS, 3% hydorgen peroxide solution), disinfection(iodophor, ethanol), debriment· Gentamycin+insulin(654-2) wet dressing 1/d 60d
Oint soaked sterilized gauze CT
Fu LJ42) (2006) · Control BS, IF(;Gentamycin 80000U+NS 1㎖ wet dressing, oral anti-)· Prevent PG· Improve BC· Nerve nutrition· Health care education(;diet) · Irrigation(80000U gentamycin+NS 50㎖), disinfection(iodophor), debriment· Apply(insulin 8U+NS 1㎖) 1/d 60d
Xiangpi shengji oint (2㎜ tk) CT
NR: not reported; CT(appearing in treatment group and control group): conventional therapy; BS: blood sugar; BP: blood pressure; LP: lipid; IF: infection ; PG: platelet aggregation ; BC: blood circulation; sol: solution; oint: ointment; inj: injection; d; day; w: week; NS: normal saline; tk: thickness