Table 1. General Characteristics of the Included Studies

Author (year)	Type of disease	Participants (T:C)	Male/Female	Mean age(y)(range)	Mean-duration of disease(y)(range)	Mean duration of ulcer	Wound area(cm2)	Grade of diabetic foot	Diagnostic criteria
Yu WX24) (2019)	DF	90(60:30)	T:34/26C:17/13	T:63.21±15.76C:62.53±14.89A:63.20±15.50(31-79)	T:18.8C:19.4A:(0.5-33)	T:21±3(d)C:22±4(d)	T:26.09±7.74C:24.76±6.81	WG 3-4	1) WHO 19992) WGS
Wang HY25) (2019)	DFU	84(42:42)	NR	62.1±6.5(45-75)	10.1±6.4(2-24)	NR	10.6±8.1(2-40)	NR	1) WHO 19992) WGS
Qie FH26) (2019)	1) DFU2) Damp-heat & blood-stasis type	60(30:30)	39/21	67.0±11.8(45-89)	13.9±6.1	NR	NR	WG 2-3	1) WGS2) TCM
Haung ZF27) (2018)	DFU	96(48:48)	T:26/22C:25/23	T:70.2±12.3C:68.8±14.3	NR	at least 4w	T:15.7±5.3C:16.0±6.3	NR	NR
Chen C28) (2018)	DF	204(102:102)	T:63/39C:61/41	T:51.01±7.38C:50.83±7.46	T:5.52±1.20C:5.44±1.15	T:2.01±0.32(y)C:2.05±0.33(y)	NR	WG 2-5T:42/47/10/3C:39/48/12/3	1) CS2) WGS
Wang Z29) (2015)	DF	200(100:100)	T:53/47C:56/44	T:54.37±4.12(42-72)C:53.12±3.98(43-70)	T:12.13±1.35(5-20)C:12.24±1.45(6-19)	NR	NR	WG 1-4	1) 1999 WHO2)WGS
Wang ZB30) (2015)	DF	200(100:100)	T:56/44C:54/46	T:57.66±14.23(41-70)C:57.12±12.79(40-70)	T:13.22±5.32(7-20)C:13.65±5.21(8-20)	NR	NR	WG 2-4T:46/38/16C:46/38/26	WGS
Zhao ZF31) (2015)	DFU	80(40:40)	37/43	77.98±11.19(41-85)	9.99±4.97(2-25)	NR	NR	WG 2-45/61/14	1) WHO 19992) WGS3) CS
Li JP32) (2015)	DF	60(30:30)	T:14/16C:15/15	T:44.1±19.2C:43.87±20.2	T:11.3±3.2mC:12.1±2.9m	NR	NR	NR	CS
Jiang YF33) (2015)	1) DFU2)T2D	131(67:64)	NR	T:61.6±16.5C:63.3±12.3	T:11.6±6.5C:12.1±7.2	T:45.7±68.3(d)C:52.5±79.6(d)	T:16.7±6.1C:15.9±8.3	NR	NR
Wang J34) (2014)	DF	64(32:32)	41/23	63±22(36-84)	17±9(1-32)	37d	(1x1-9x7)	NR	1999 WHO
Cao BL35) (2014)	DFU	40(21:19)	T:14/7C:10/9	T:58.62±8.15C:60.21±8.93	NR	T:58.62±8.15(d)C:60.21±8.93(d)	T:58.62±8.15C:60.21±8.93	NR	NR
Long CX36) (2014)	DFU	60(30:30)	36/24	56.2±12.5(32-85)	15.2±4.9(1-25)	(3-6m)	NR	WG 1-3T:9/20/1C:10/19/1	WGS
Zhu XJ37) (2013)	1) DF2) Damp-heat & poisonous type	56(28:28)	T:16/12C:17/11	T:60±8.4(50-79)C:58.4±8.4(51-78)	T:10.6±3.2(3-20)C:12.5±7.5(4-20)	T:2.8±1.6yr(3m-5y)C:12.5±7.5yr(1m-5.5y)	NR	WG 1-4	1) 1999 WHO2) TCM3) WGS
Wang A38) (2012)	1) DFU2)T2D	60(30:30)	T:16/14C:18/12	T:57±6(45-78)C:59±7(46-79)	T:10±5(3-15)C:11±6(3-13)	T:1-5mC:1-4m	over 1.0X1.0under 6.0X6.0	WG 1-3	1) 1999 WHO2) WGS3) CS
Gao GY13) (2012)	1) DFU2)T2D	60(30:30)	T:18/12C:16/14	T:60(45-75)C:61(46-70)	T:15 (3-20)C:16(4-21)	T:3-10mC:3-10m	over 1.0X1.0under 6.0X6.0	WG 1-3	1) 1999 WHO2)WGS
Li SF39) (2011)	1) DFU2)T2D	48(24:24)	T:18/6C:13/11	T:60±13(41–80)C:60±11(38–76)	T:9.5±4.3C:10.0±6.9	T:7m(3–108m)C:7.5m(3–60m)	T:3.8±3.72C:5.4±4.95	WG 1-3T:8/10/6C:3/13/8	WGS
Su DB40) (2010)	DF	60(30:30)	T:14/16C:13/17	44-76	NR	NR	3±1.5	UTC C,D	1) WHO 19992) UTC
Yuan XM41) (2009)	1) DF2)Damp-heat type	58(30:28)	T:19/11C:18/10	T:60.3±9.1(46-78)C:62.1±8.8(45-77)	T:15.33±5.18(5-20)C:15.97±4.94(5.5-19)	T:2.5±1.2m(1w-13m)C:2.6±1.3m(1w-10m)	T:57.2±5.30C:56.4±5.23	WG 2-4T:7/17/6C:7/16/5	1) WHO 19992) CS3) WGS4) TCM
Fu LJ42) (2006)	DFU	56(34:22)	T:20/14C:12/10	T:57.6±3.62(41-80)C:58.5±3.56(40-82)	T:9.7±4.8(4-27)C:10.1±5.2(5-27)	NR	NR	WG 1-4T : 10/16/5/3C : 8/11/2/1	1) 1997 ADA2) WGS

T: treatment group; C: control group; NR: not reported; d: days; w: weeks; m; months; y: year; WGS: Wagner's grade scale; UTC: University of Texas classification; TCM: TCM syndorme differentiation type; CS: Chinese academic association standard; T2D: type 2 Diabetes; DF: diabetes foot; DFU: diabetes foot ulcer; 1999 WHO:1999 WHO diagnostic criteria for diabetes; 1997 ADA: 1997 ADA diabetes diagnosis standard