| Qiu (1990) | <Acute conjunctivitis>97 cases 179 eyes(A) 121 eyes(B) 58 eyes<Chronic conjunctivitis>33 cases 60 eyes(A) 35 eyes (B) 25 eyes | 紅眼逍 滴眼液(Hongyanxiao eye drops)(Detail informations were no reported) | Chloramphenicol eye drops(Detail informations were no reported) | NR | Effective rate N(%)*非治愈=好轉+无效(Detail informations were no reported)*Counted by the number of eyes | <Acute conjunctivitis>治愈(Totally cured): (A) 115(95.64%) (B) 47(81.03%)非治愈(Not cured): (A) 6(4.96%) (B) 11(18.97)(A)>(B) (p<0.05)<Chronic conjunctivitis>治愈(Totally cured): (A) 28(80.00%) (B) 15(60.00%)非治愈(Not cured): (A) 7(20.00%) (B) 10(40.00%) | NR |
| M(62) F(68) |
| 2mons-76yrs old |
| Liu (1999) | Acute cathartic conjunctivitis300 cases 533 eyes(A) 200 cases345 eyes(B) 100 cases188 eyes | 复方熊胆 滴眼液(Fufang Xiongdan eye drops)1 drop6 times/day | Rifampicin eye drops2 drops6 times/day | 5 Ds | Effective rate N(%)① 治愈：Subjective symptoms and topical Inflammation diapeared; Hemorrhagic absorption of subconjunctiva and globular conjunctiva;Integration points ≤2; Normal conjunctival epithelial scraper② 显效：Significant improvement of subjective symptoms and topicalInflammation; Hemorrhagic absorption of subconjunctiva and globular conjunctiva;Integration points≥2/3.③ 有效：Subjective symptoms and topical inflammation improved; Hemorrhagic absorption of subconjunctiva and globular conjunctiva;Integration points≥1/3.④ 无效：No improvement in symptoms and topical Inflammation; Integration points<1/3.*Counted by the number of eyes | ① 痊愈: (A) 194(56.23%) (B) 61(32.45%)② 显效: (A) 87(25.22%) (B) 53(28.19%)③ 有效: (A) 56(16.23%) (B) 60(31.91%)④ 无效: (A) 8(2.32%) (B) 14(7.45%)※ Total effective rate(①+②): (A) 81.45% (B) 60.54% (p<0.01) | - No local or systemic adverse effects were found in the treatment group.- A total of 82 patients before and after treatment were reviewed for no abnormal changes in liver and kidney function |
| (A) M(105) F(95)(B) M(52) F(48) |
| (A) 36.42±15.0(B) 4.69±14.15 |
| Yi (2000) | (1) Herpes simplex Keratitis(HSK) 42 cases①dendritic keratitis(32)②cartography keratitis(6)③Disciform keratitis(4)(2) Epidemic keratoconjunctivitis 40 cases | 中药抗病毒滴眼液(Chinese Medicine Antivirus eye drops)10 times/day | 0.1% acyclic guanosine(ACV) eye drops10 times/day+ 0.25% chloramphenicol eye drops(+ 0.025% dexamethasone eye drops, Vit B2, C, AD in disciform keratitis) | 2 wks | Effective rate N(%)① 治愈：Irritation of symptoms disappearing, Corneal ulcer repair, fluorescent staining (-) or corneal epithelial infection parenchymal infiltrates absorption, KP(-)② 好转： Conscious symptoms improved, ulcer partial repair, infiltrated edema reduces, KP(-) or decreases③ 无效：symptoms and signs did not improve or worsen after 2 weeks of medication.※ Total effective rate=(①+②)/(①+②+③)*100 | (1) HSK① Dendritic keratitis(A) 治愈 10 + 好转 4(87.50%)(B) 治愈 8 + 好转 6(87.50%)→ no significant differences②③ Cartography & Disciform keratitis(A) 85.71% (B) 80.95%→ No significant differences(p>0.05)→ Not comparable for few cases(2) Epidemic keratoconjunctivitis(A) 治愈 13 + 好转 5(90.00%)(B) 治愈 9 + 好转 5(70.00%)→ No significant differences(p>0.05) | - In 12 cases of (A), burning sensations, tingling, and discomfort occurred.- The burning sensation and tingling pain disappear for a short time after the use of the drug.- There are no side effects such as complications during the medication |
| NR |
| NR |
| Gong (2005) | Epidemic kerato-conjunctivitis40cases 47eyes(A) 20 cases 25 eyes(B) 20 cases 22 eyes | 魚醒草 滴眼液(Houttuynia cordata Thunb eye drops)1 drop6 times/day | 0.5％ Ribavirin eye drops1 drop6 times/day | 10 Ds | Effective rate N(%)① 痊愈：Symptoms and signs disappeared at 1st, 2nd, 3rd reexamination(score 0)② 显效：Scores decreased≥85％ and＜100％③ 进步：Scores decreased≥50％ and＜85％④ 无效：Scores decreased<50％ or symptoms and signs increased.※ Total effective rate=(①+②)/(①+②+③+④)*100 | ① (A) 18(72%) (B) 17(77.27%)② (A) 2(8%) (B) 1(4.55%)③ (A) 5(2%) (B) 4(18.18%)④ (A) 0 (B) 0※ Total effective rate(A) 20(80.0%) (B) 18(81.8%)(p=0.242) | - There have been no local and general side effects of patients during this research- No single case has been reported to have decreased eyesight- Only one case with mild tingling |
| M(19 cases/21 eyes)F(21 cases/26 eyes) |
| NR |
| Qi (2007) | Acute bacterial conjunctivitis200 case 245 eyes(A) 100 case(B) 100 case | 板蓝根 滴眼液(Isatis indigotica Fort. eye drops)1 drop6 time/day | 0.3% Levofloxacin hydrochloride eye drops1 drop6 time/day | 7 Ds | Effective rate N(%)① 痊愈：Symptoms & sign decreased ≥95%② 显效：Symptoms & sign decreased ≥70％ and＜95％③ 有效：Symptoms & sign decreased ≥30％ and＜70％④ 无效：Symptoms & sign decreased＜30％※ Total effective rate=(①+②)/(①+②+③+④)*100 | ① (A) 75(75%) (B) 81(81%)② (A) 15(15%) (B) 12(12%)③ (A) 7(7%) (B) 3(3%)④ (A) 3(3%) (B) 4(4%)※ Total effective rate(A) 90% (p<0.05) (B) 93% (p<0.05)- Between A and B : p>0.05<Visual acuity change>: (A) 0.90±0.25 → 0.95±0.25(p<0.05)(B) 0.91±0.26 → 0.96±0.26(p<0.05)- Between A and B : p>0.05 | - Mild feeling of irritation and tingling in 2 cases of (A) group → disappeared after 3 minute of rest after closing the eyes- Mild eye tingling in 2 cases of (B) group → disappeared after 1 minute of rest after closing the eyes- No clinical adverse events in both (A) and (B)- Blood, urine and liver and kidney function tests after the treatment showed no clinically significant abnormalities in both (A) and (B) |
| Tan (2010) | Conjunctivitis126 cases(A) 63 cases 126 eyes(B) 63 cases 126 eyes | 魚醒草 滴眼液(Houttuynia cordata Thunb eye drops)2 drops6 times/day | Ribavirineye drops2 drops6 times/day | 2-5 Ds | Effective rate N(%)① 显效： No clinical symptoms and secretions; totally cured, no recurrence.② 有效：Symptoms improved, secretions decreased; completely healed with other medications.③ 无效：No improvement in clinical symptoms※ Total effective rate=(①+②)/(①+②+③)*100 | ① (A) 51(80.95%) (B) 34(53.97%)② (A) 9(14.29%) (B) 13(20.63%)③ (A) 3(4.76%) (B) 16(25.40%)※ Total effective rate: (A) 65.24% (B) 74.60%→ Significant differencesbetween (A) and (B) (p<0.05) | No significant adverse reactions |
| M(72 cases 144 eyes)F(54 cases 108 eyes) |
| 17-62 yrs old |
| Wang (2020) | Acute bacterial conjunctivitis80 cases(A) 40 (B) 40 | 复方熊胆 滴眼液(Fufang Xiongdan eye drops)1 drop6 times/day | Levofloxacin eye drops2 drops3 times/day | 3 Ds | Effective rate N(%)① 治愈 : Symptoms disappeared① 显效 : Symptoms has improved significantly③ 有效 : Symptoms has improved④ 无效 : No improvement in clinical symptoms※ Total effective rate= (①+②+③)/(①+②+③+④)×100 | ① (A) 24(60.00%) (B) 19(47.50%)② (A) 8(20.00% (B) 9(22.50%)③ (A) 7(17.50%) (B) 6(15.00%)④ (A) 1(2.50%) (B) 6(15.00%)※ Total effective rate: (A) 97.50% (B) 85.00%→ Significant differences between (A) and (B) (p<0.05) | NR |
| (A) M(18) F(22)(B) M(19) F(21) |
| 20-41 yrs old(31.3±3.87 yrs old) |