| Tang6) (2017) | C : 30 | - Vasodilator : Kaishi- Vitamin : B1, B12 | 14days | 1) Curative effect index(CEI)2) Symptom score(deafness, tinnitus, dizzness)3) Hemorheology(Blood coagulation time) | CEI-Healing: 95%≤symptom score reduction-Significant effective: 70%≤symptom score reduction<95%;-Effective: 30%≤symptom score<70%-Ineffective: symptom product reduction<30%*Symptom : deafness, tinnitus, dizzness | (43.84±12.11)㏈→NR∥ | CEIC : 66.7%T : 86.7%(p<0.05) | NR |
| T : 30 | - HM‡(OA§) bid with C | (40.39±10.57)㏈→NR |
| Wang7) (2017) | C : 35 | - Vasodilator : Alprostadil- Vitamin : Mecobalamin, Niacin | 14days | 1) TER¶2) PTA**2) Total symptom scores(tinnitus, dizziness, ear fullness) | TER-Healing: normal hearing-Significantly effective: PTA is increased by more than 30㏈-Effective: PTA is increased by 15-30㏈-Ineffective: PTA is increased by less than 15㏈ | (70.5±19.6)㏈→(62.2±21.2)㏈ | TERC : 71.4%T : 91.7%(p<0.05) | NR |
| T : 35 | - HM(OA) bid | (71.2±20.3)㏈→(50.6±19.4)㏈ |
| Lian8) (2017) | C : 33 | - Blood Circulating Agent : Ginkgo biloba capsule- Vitamin : Methylcobalamin | 14days | 1) TER2) PTA3) Total symptom percent(tinnitus, dizziness, ear fullness) | TER-Healing: PTA returns to normal, or reaches the level of healty ear, or reaches the level before the illness.-Significant effecttive: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-29㏈-Ineffective: PTA is improved by less than 14㏈ | (56.4±14.57)㏈→(35.75±20.61)㏈ | TERC : 33.33%T : 84.85%(p<0.05) | NR |
| T : 33 | - HM(OA) bid | (58.26±16.21)㏈→(49.32±22.73)㏈ |
| Zhao9) (2018) | C : 82 | - Vitamin : Methylcobalamin- Corticosteroid : Dexamethasone- Vasoactive drug : Buflomedil | 15days | 1) TER2) PTA | NR | (63.29±17.37)㏈→(40.24±15.61)㏈ | TERC : 82.72%T : 98.78%(p<0.05) | NR |
| T : 81 | - HM(OA) qd with C | (63.24±17.36)㏈→(31.47±14.55)㏈ |
| Yao10) (2018) | B : 50 | - Corticosteroid : Dexamethasone- Anti-vertigo medication : Betahistine- Vitamin : mecobalamin, B1 | 14days | 1) TER | TER-Healing: normal PTA at 250-4,000㎐, hearing is restored to before the illness, and symptoms disappear.-Effective: PTA at 50-4000㎐ is improved by more than 15㏈, and symptoms are improved.-Ineffective: Symptoms are not relieved or even worsened.*Symptom : tinnitus, dizziness | NR | TERB : 78.0%A : 96.0%(p<0.05) | B : 18.0%A : 4.0%(p<0.05) |
| A : 50 | - HM(OA) bid with B | NR |
| Tian11) (2018) | C : 30 | - Anti-vertigo medication : Betahistine- Blood Circulating Agent : Shuxuening | 28days | 1) TER2) Disease socres(deafness, tinnitus, dizziness) | TER-Healing: Symptoms return to normal, and disease scores are reduced by 90% or more than before treatment.-Significantly effective: Symptoms return to normal , and disease scores are reduced by 70-89%.-Effective: Symptoms have improved, and symptom score is reduced by 30-69%.-Ineffective: Does not meet the above requirements.*Symptoms : deafness, tinnitus, dizziness | NR | TERC : 76.67%T : 96.67%(p<0.05) | Not serious side effect |
| T : 30 | - HM(OA) bid with C | NR |
| Xue12) (2018) | C : 38 | - Corticosteroid : Dexamethasone - Coenzyme : Coenzyme A | 14days | 1) TER2) Hemorheology(Whole blood viscosity) | TER-Healing: Symptoms disappear completely, and PTA is completely restored.-Significantly effective: Symptoms have basically disappeared, and PTA is improved by more than 30㏈.-Effective: Symptoms have improved, and P is improved by 15-30㏈.-Ineffective: No relief of clinical symptoms, even serious.*Symptoms : tinnitus, dizziness, nausea, vomiting, nystagmus | NR | TERC : 78.95%T : 97.37%(p<0.05) | Not serious side effect |
| T : 38 | - HM(OA) bid with C | NR |
| Ye13) (2019) | C : 30 | - Blood Circulating Agent : Ginkgo biloba extract tablets, Citicoline sodium tablets- Anti-vertigo medication : Betahistine, Flunarizine capsules- Corticosteroid : Dexamethasone(Injection intratympanic) | 14days | 1) TER2) PTA3) Symptoms(tinnitus, dizziness, ear fullness) | TER-Healing: Symptoms disappeared, PTA returned to normal.-Significant effective: Symptoms basically disappeared, PTA is improved by more than 30㏈.-Effective: Symptoms improved, PTA is increased by 15-30㏈-Ineffective: No significant change*Symptoms : tinnitus, dizziness, ear fullness | (67.03±15.61)㏈→(49.23±21.61)㏈ | TERC : 63.33%T : 76.67%(p>0.05) | NR |
| T : 30 | - HM(OA) bid with C | (67.80±15.02)㏈→(46.17±21.47)㏈ |
| Lai14) (2019) | C : 50 | - Vasodilators- Hormonal drugs | 14days | 1) TER | TER-Healing: normal hearing, normal PTA, tinnitus and dizziness disappear.-Effective: PTA is improved by more than 30㏈, tinnitus and dizziness are alleviated, and sleep is not affected.-Ineffective: PTA is increased by less than 15㏈, tinnitus and dizziness are not improved, which affects sleep | NR | TERC : 84.0%T : 96.0%(p<0.05) | Not serious side effect |
| T : 50 | - HM(OA) bid with C | NR |
| Jiang15) (2019) | C : 30 | - Vasodilators : Vinpocetine | 10days | 1) TER2) PTA3) Dizziness | TER-Healing: PTA at 0.25-4k㎐ returns to the normal level or reaches the level before the illness.-Significant effective: PTA at 0.25-4k㎐ is improved by more than 30㏈.-Effective: PTA at 0.25-4k㎐ is improved by 15-30㏈.-Invalid: PTA at 0.25-4k㎐ is improved by less than 15㏈. | (62.46±9.64)㏈→(52.16±8.02)㏈ | TERC : 50.0%T : 66.7%(p<0.05) | NR |
| T : 30 | - HM(OA) bid with C | (63.25±8.86)㏈→(45.71±8.17)㏈ |
| Wang16) (2019) | C : 70 | - Corticosteroid : Methylprednisolone(Injection. skin behind the ears) | 14days | 1) TER2) PTA3) Hemorheology(plasma viscosity, blood coagulation time, hematocrit, Homocysteine) | TER-Healing: noraml PTA or reaches the level of the healthy ear-Significantly effect: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-30㏈.-Ineffective: PTA is improved by less than 15㏈. | (73.48±9.70)㏈→(41.37±7.65)㏈ | TERC : 78.57%T : 85.71%(p<0.05) | C : 11.43%T : 4.29%(p>0.05) |
| T : 70 | - HM(OA) bid with C | (74.53±8.96)㏈→(33.61±6.42)㏈ |
| Chen17) (2020) | C : 41 | - Corticosteroid : Prednisone acetate tablets- Vasodilator : Alprostadil | 10days | 1) TER2) PTA3) Deafness4) Total symptoms scores(deafness, tinnitus, ear fullness, dark red lips) | TER-Healing: Symptoms disappeared, impaired PTA returned to normal.-Significant effective: Symptoms basically disappeared, PTA is improved by more than 30㏈.-Effective: Symptoms improved, PTA is increased by 15-30㏈-Ineffective: No significant change*Symptoms : deafness, tinnitus, ear fullness, dark red lips | (65.12±8.31)㏈→(48.28±7.62)㏈ | TERC : 73.2%T : 90.2%(p<0.05) | NR |
| T : 41 | - HM(OA) bid with C | (67.32±8.23)㏈→(41.61±5.37)㏈ |
| Qi18) (2020) | C : 34 | - Vitamin : Mecobalamin vitamin C- Vasodilator : Alprostadil- Corticosteroid : Dexamethasone | 14days | 1) TER2) PTA3) Hemorheology(plasma viscosity, fibrinogen, hematocrit) | TER-Healing: normal PTA, or returns to the level of the uninfected side, or the level before the illness.-Significant effective: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-30㏈.-Ineffective: PTA is improved by less than 15㏈. | (63.25±10.48)㏈→(40.53±8.14)㏈ | TERC : 70.59%T : 91.18%(p<0.05) | C : 17.65%T : 14.71%(p>0.05) |
| T : 34 | - HM(OA) bid with C | (63.14±10.29)㏈→(48.75±9.26)㏈ |
| Fu19) (2020) | C : 43 | - Vasodilator : Alprostadil- Nerve growth factor | 14days | 1) TER2) Hemorheology(whole blood viscosity, plasma viscosity, fibrinogen, hematocrit)3) Total symptoms scores(deafness, tinnitus, dizziness, dark red tongue, petechia) | TER-Healing: PTA returns to normal or healthy ears or before the onset, the syndrome score reduction is greater than 90%.-Significant effective: PTA is increased by more than 30㏈, and the syndrome score is reduced by 60% to 89%.-Effective: PTA is increased by 15-29㏈, and the syndrome score decreases by 30% to 59%.-Ineffective: PTA did’t increase significantly, and the syndrome score decreased by less than 29%.*Symptoms : deafness, tinnitus, dizziness, dark red tongue, petechia | NR | TERC : 72.09%T : 93.18%(p<0.05) | NR |
| T : 44 | - HM(OA) bid with C | NR |
| Sun20) (2020) | C : 37 | - Corticosteroid : Prednisone- Vasodilator : Alprostadil- Vitamin : Mecobalamin | 14days | 1) TER2) PTA3) Plasma lipids4) Atherogenic index of plasma | TER-Healing: normal hearing-Significantly effective: PTA is increased by more than 30㏈.-Effective: PTA is increased by 15-30㏈.-Ineffective: PTA is increased by less than 15㏈ | (62.43±11.88)㏈→(49.08±14.71)㏈ | TERC : 67.50%T : 78.05%(p<0.05) | NR |
| T : 37 | - HM(OA) bid with C | (63.37±10.82)㏈→(40.54±13.70)㏈ |
| Guo21) (2020) | C : 44 | - Vasodilator : Alprostadil- Vitamin : Mecobalamin, Niacin | 14days | 1) TER2) PTA3) Symptom score(deafness, tinnitus, dizzness) | TER-Healing: Symptoms disappear, and PTA returns to normal-Effective: Symptoms are improved, PTA is increased by more than 15㏈-Ineffective: Inconsistent with the above description. | (72.94±14.77)㏈→(62.02±15.92)㏈ | TERC : 75.00%T : 95.45%(p<0.05) | NR |
| T : 44 | - HM(OA) bid | (73.22±12.08)㏈→(50.25±16.24)㏈ |
| Lin22) (2020) | C : 30 | - Vitamin : Methylcobalamin- Blood Circulating Agent : Ginkgo biloba extract- Corticosteroid : Methylprednisolone | 10-14days | 1) TER2) PTA3) Symptom score( tinnitus, dizzness, ear fullness) | TER-Healing: PTA returns to normal, or reaches the level of healty ear, or reaches the level before the illness.-Significantly effective: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-30㏈.-Ineffective: PTA is improved by less than 15㏈. | (55.23±15.61)㏈→(38.47±18.35)㏈ | TERC : 60.0%T : 79.49%(p<0.05) | NR |
| T : 78 | - HM(OA) with C | (54.64±12.73)㏈→(33.18±13.55)㏈ |
| Zhao23) (2020) | C : 60 | - Corticosteroid : Dexamethasone- Blood Circulating Agent : Troxerutin cerebroprotein hydrolysate- Nerve growth factor | 14days | 1) TER2) Tinnitus | TER-Healing: normal hearing or reaches the level before the illness-Significantly effective: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-30㏈.-Ineffective: PTA is improved by less than 15㏈. | NR | TERC : 66.66%T : 90.0%(p<0.05) | C : 6.67%T : 13.34%(p>0.05) |
| T : 60 | - HM(OA) bid with C | NR |
| Dong24) (2021) | C : 30 | - Corticosteroid : Dexamethasone(injecion IV & intratympanic)- Blood Circulating Agent : Troxerutin cerebroprotein hydrolysate, Shuxuening- Nerve growth factor | 14days | 1) TER2) Symptom score(dizziness, tinnitus, deafness) | TER-Healing: PTA at 0.5-4k㎐ reaches normal, or to the hearing value of healthy ears, or to the hearing value before illness-Significant effective: PTA at 0.5-4k㎐ is improved by more than 30㏈-Effective: PTA is improved by 15-30㏈-Ineffective: PTA is improved by less than 15㏈. | NR | TERC : 63.33%T : 86.67%(p<0.05) | NR |
| T : 30 | - HM(OA) bid with C | NR |
| Huang25) (2021) | C : 31 | - Corticosteroid : Prednisone- Viatamin : Mecobalamin- Blood Circulating Agent : Ginkgo biloba extract | 14days | 1) TER2) PTA3) Hemorheology(Fibrinogen, Plasma viscosity, whole blood viscosity)4) Symptoms score(ear fullness, tinnitus, dizziness, nausea<vomiting) | TER-Significantly effective: symptoms disappeared or syndrome scores are reduced by more than 70%, and normal hearing.-Effective: symptoms are significantly improved, syndrome scores are reduced by more than 50%, PTA is improved by more than 15㏈-Ineffective: PTA is improved less than 15㏈, symptoms are not improved or even worse.*Symptom : ear fullness, tinnitus, dizziness, nausea, vomiting | (64.33±8.65)㏈→(44.37±5.77)㏈ | TERC : 74.19%T : 96.77%(p<0.05) | C : 12.90%T : 6.45%(p>0.05) |
| T : 31 | - HM(OA) hs with C | (64.27±8.76)㏈→(39.74±5.82)㏈ |
| Pan26) (2021) | C : 36 | - Vasodilators- Nerve nutrition- Anticoagulation- Corticosteroid | 14days | 1) TER2) PTA | TER-Healing: normal hearing, symptoms disappear-Significant effective: PTA is increased by more than 30㏈, symptoms are significantly reduced.-Effective: PTA is increased by 15-30㏈, symptoms are reduced.-Ineffective: Does not meet the above criteria | (63.78±9.61)㏈→(42.23±6.65)㏈ | TERC : 76.7%T : 95.1%(p<0.05) | TERC : 16.77%T : 11.1%(p>0.05) |
| T : 36 | - HM(OA) bid with C | (62.05±8.63)㏈→(31.17±4.13)㏈ |
| Xia27) (2021) | C : 40 | - Corticosteroid : Dexamethasone | NR | 1) TER2) Symptom(tinnitus, deafness, ear fullness) | TER-Healing: PTA returns to the normal level, or reaches the level of healthy ear, or reaches the level before the illness.-Significantly effective: PTA is improved by more than 30㏈.-Effective: PTA is improved by 15-30㏈.-Ineffective: PTA is improved by less than 15㏈. | NR | PTAC : 72.5%T : 87.5%(p<0.05) | NR |
| T : 40 | - HM(OA) with C | NR |