| classification according to the passage of time (acute, chronic) |
| acute itching |
| The cell biology of acute itch | Green D,Dong X | J Cell Biol | 2016 | 6 |
| chronic itching : TRP channel and astrocyte in spinal dorsal horn |
| The role of trpa1 in skin physiology and pathology | Maglie R,Araujo D,Antiga E,Geppetti P,Nassini R,Logu F, et al | International Journal of Molecular Sciences | 2021 | 9 |
| Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1 | Xie BLi X | J Dermatol | 2019 | 10 |
| Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation | Silverman H,Chen A,Kravatz N,Chavan,Sangeeta S,Chang E, et al | Front Immunol | 2020 | 11 |
| Spinal dorsal horn astrocytes: New players in chronic itch | Tsuda M. | Allergol Int | 2017 | 12 |
| Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions | Shiratori H,Tsuda M | Journal of Pharmacological Sciences | 2020 | 13 |
| classification according to the immune factors involved (inflammatory, non-inflammatory) |
| Pruritus as a distinctive feature of type 2 inflammation | Garcovich S,Maurelli M,Gisondi P,Peris K,Yosipovitch G,Girolomoni G, et al | Journal of Pharmacological Sciences | 2021 | 14 |
| Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch | Oetjen LK,Mack MR,Feng J,Whelan T,Niu H,Guo C et al | Cell | 2017 | 15 |
| The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching | Xu J,Zanvit P,Hu L,Tseng P,Liu N,Wang F, et al. | Immunity | 2020 | 16 |
| classification according to the neurophysiological mechanism(pruritoceptive itching, neuropathic itching, neurogenic itching and psychogenic itching) |
| histamine and neurophysiological mechanism |
| The Return of the Mast Cell: New Roles in Neuroimmune Itch Biology | Wang F,Yang T,Kim BS | J Invest Dermatol | 2020 | 17 |
| Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue | Landucci E,Laurino A,Cinci L,Gencarelli M,Raimondi L. | Front Cell Neurosci | 2019 | 18 |
| Recent advances in mast cell activation and regulation | Kim HS,Kawakami Y,Kasakura K,Toshiaki K, et al | F1000Research | 2020 | 19 |
| Mast cell-neural interactions contribute to pain and itch | Gupta K,Harvima I | Immunol Rev | 2018 | 20 |
| A mast-cell-specific receptor mediates neurogenic inflammation and pain | Green D,Limjunyawong N,Gour N,Pundir P,Dong X | Neuron | 2019 | 21 |
| Gastrointestinal tract and Mechanism of Itching |
| Leaky Gut Syndrome and Itching |
| A Viewpoint on the Leaky Gut Syndrome to Treat Allergic Asthma: A Novel Opinion | Farshchi M,Azad F,Salari R,Mirsadraee M,Anushiravani M et al. | J Evidence-Based Complement Altern Med | 2017 | 26 |
| Intestinal Permeability Defects: Is It Time to Treat? Clin Gastroenterol Hepatol | Odenwald M,Turner J | Clin Gastroenterol Hepatol. | 2013 | 27 |
| Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation | Zhu T,Zhu T,Tran K,Sivamani R,Shi V | British Journal of Dermatology | 2018 | 28 |
| IL-31: A new key player in dermatology and beyond | Basci I,Ruzicka T | Journal of Allergy and Clinical Immunology | 2018 | 29 |
| Neuropeptides and Itching |
| Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System | Shamsi BH,Chatoo M,Xu XK,Xu X,Chen XQ. | Front Endocrinol (Lausanne) | 2021 | 30 |
| Spinal somatostatin-positive interneurons transmit chemical itch | Fatima M,Ren X,Pan H,Slade H,Asmar A,Xiong C, et al. | Pain | 2019 | 31 |
| Gastrointestinal peptides and itch sensation | Weber HC | Current Opinion in Endocrinology, Diabetes and Obesity | 2015 | 32 |
| Expression pattern of somatostatin receptor subtypes 1-5 in human skin: An immunohistochemical study of healthy subjects and patients with psoriasis or atopic dermatitis | Hagstromer L,Emtestam L,Stridsberg M,Talme T | Exp Dermatol | 2006 | 33 |
| The gut-itch connection | Sanders K,Nattkemper L,Yosipovitch G. | Experimental Dermatology | 2016 | 34 |
| Microbiota and Itching |
| The Skin Microbiota and Itch: Is There a Link? | Kim HS,Yosipovitch G. | J Clin Med | 2020 | 35 |
| The gut microbiome as a major regulator of the gut-skin axis | Salem I,Ramser A,Isham N,Ghannoum M. | Frontiers in Microbiology | 2018 | 36 |
| The gut-skin axis in health and disease: A paradigm with therapeutic implications | O'Neill C,Monteleone G,McLaughlin J,Paus R | BioEssays | 2016 | 37 |
| Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88TM) on dry skin conditions: A randomized,double-blind,placebo-controlled study | Ogawa M,Saiki A,Matsui Y,Tsuchimoto N,Nakakita Y,Takata Y, et al. | Exp Ther Med | 2016 | 38 |
| Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis | Song H,Yoo Y,Hwang JH,Na YC,Kim HN | J Allergy Clin Immunol | 2016 | 39 |