Table 6. Treatment Periods and Changes of Tongue Lesion Size, NRS, OAG, OHIP-14(OPD Tx)

Treatment Period	Changes of Tongue Lesion Size, NRS, OAG, OHIP-14
2020.9.8-2020.9.22	Tongue Lesion Size: 2.4㎝×3.3㎝→2.4㎝×3.3㎝NRS(Stable state): 4→4NRS(Exacerbated state): 5→6OAG: 18→18, OHIP: 26→26
2020.9.22-2020.11.9	Tongue Lesion Size: 2.4㎝×3.3㎝→1.1㎝×1.9㎝NRS(Stable state): 4→3NRS(Exacerbated state): 6→4OAG: 18→15, OHIP: 26→20
2020.11.9-2020.11.23	Tongue Lesion Size: 1.1㎝×1.9㎝→1.1㎝×1.8㎝NRS(Stable state): 3→3NRS(Exacerbated state): 4→3OAG: 15→14, OHIP: 20→18
2020.11.23-2020.12.24	Tongue Lesion Size: 1.1㎝×1.8㎝→0.5㎝×0.7㎝NRS(Stable state): 3→2NRS(Exacerbated state): 3→3OAG: 14→12, OHIP: 18→15
2020.12.24-2021.1.20	Tongue Lesion Size: 0.5㎝×0.7㎝→0.2㎝×0.4㎝NRS(Stable state): 2→1NRS(Exacerbated state): 3→2OAG: 12→10, OHIP: 15→9
2021.1.20-2021.1.27	Tongue Lesion Size: 0.2㎝×0.4㎝→NoneNRS(Stable state): 1→1NRS(Exacerbated state): 2→1OAG: 10→9, OHIP: 9→6
2021.1.27-2021.2.3	Tongue Lesion Size: None→NoneNRS(Stable state): 1→0NRS(Exacerbated state): 1→1OAG: 9→9, OHIP: 6→5
2021.2.3-2021.3.4	Tongue Lesion Size: None→NoneNRS(Stable state): 0→0NRS(Exacerbated state): 1→1OAG: 9→9, OHIP: 5→5

The treatment periods in the above table were divided based on the changes in the size of the tongue lesion, NRS, OAG, and OHIP, during the different Korean medicine applied or discontinuation. The period of OPD Tx may differ by several days from the time of change or discontinuation of Korean medicine treatment because changes in size of the tongue lesion, NRS, OAG, and OHIP-14 were recorded based on the visit date.