Table 2. Characteristics of Articles for Acupuncture Treatment for Dry Eye Syndrome

Author Sample Size Acupuncture Style Acupoints/Regions(I) Treatment Session & Period (I) Time (I) Intervention Group Control Group Outcome Measurements Main Results (I/C) Adverse Events
Lu (2019, China) 88 (44/44) Intradermal needle Cuanzhu(BL2)Sizhukong(TE23)Sibai(ST2)Yuyao(EX-HN4)Taiyang(EX-HN5) 3 times per week, for 2 weeks (total 6 times) 1-2 days AT+AD AD (0.1% sodium hyaluronate) 1. Total efficacy rate 1. I>C97.73%>84.09%(P<0.05) N.R
Ma (2018, China) 80 (40/40) Thumb-tack needle ① Cuanzhu(BL2), Sizhukong(TE23), Sibai(ST2)② Yintang(EX-HN3), Yuyao(EX-HN4), Taiyang(EX-HN5) Once a week(①, ② were used alternately), for 2 weeks (total 2 times) 2-3 days Subcutaneous embedding of thumb-tack needle AD 1. Subjective symptom score2. SIT3. BUT4. FL5. Total efficacy rate After 2 weeks from the final treatment,1. I>C0.39±0.30<0.51±0.27(P<0.05)2. I>C13.03±1.33>11.48±0.51(P<0.05)3. I>C12.67±3.46>9.41±1.22(P<0.05)4. I>C0.32±0.10><0.58±0.25(P<0.05)5. I>C90.0%>85.0%(P<0.05) N.R
Lee (2017, Korea) 100 (50/50) Auricular acupuncture machine (Acupuctoscope system B & AM3D, Acumedic Company, UK) Shenmen(TF4)Zero(H1)Liver(CO12)Master Sensorial(Eye, L5) 2 times a week, for 4 weeks (total 8 times) 30 sec. per each point (total 4 min.) Acupressure with ES Acupressure without ES 1. Subjective symptom score2. BUT3. SIT 1, I<C(P<0.05)2, I>C(P<0.05)3. I>C(P<0.05) No adverse event. Minor adverse effects(2 patients, mild pricking pain)
Wu (2016, China) 40 (20/20) Thumb-tack needle Cuanzhu(BL 2)Sibai(ST 2)Taiyang(EX-HN 5) Every other day, for 2 weeks (total 7 times) 1 day Subcutaneous embedding of thumb-tack needle AD 1. OSDI2. SIT3. BUT 1, I=C(P<0.05)2, I=C(P<0.05)3. I=C(P<0.05) N.R
I: Intervention group, C: Control group, AT: Acupuncture, AD: Artificial tear drop, ES: Electrical stimulation, SIT: Schirmer I test, BUT: Tear film break-up time, FL: Fluoresceine staining, OSDI: Ocular Surface Disease Index, N.R: Not reported.