| 1 | Vilianen M1 (2005) | Probiotics in the treatment of atopic eczema/dermatitis syndrome in infant~41) | 2LGG For 230 infants with milk allergy, SCORAD was checked in the experimental group fed with LGG lactobacillus and placebo-controlled group for 4 weeks |
| In all subjects, the SCORAD score was reduced. Meanwhile, it was significantly lowered in the infants with IgE-sensitized allergies than those in the control group. |
| 2 | Weston S1 (2005) | Effects of probiotics on atopic dermatitis: a randomised contralled trial~~42) | For 53 children aged 6-18 months with severe atopic dermatitis, the double-blind method was used to check SCORAD score in Lactobacillus intake group and placebo-controlled group |
| Latobacillus fermentum VRI-033 PCC was given to the experimental group for 8 weeks and the same amount of placebo was also given to the placebo control group during the same period. The SCORAD score was significantly decreased in the experimental group taking the lactic acid bacteria than in the placebo control group, showing the biggest difference at the end of the 16 weeks. After the experiment, the lactobacillus intake group changed from severe atopic to mild. |
| 3 | Folster-Holst R1 (2006) | Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants~~43) | For a total of 54 severe atopic infants aged 1-55 months, LGG was orally administered to the experimental group and placebo to the control group for 8 weeks. Emollients, 1,2-stage topical corticosteroids, antihistamines were allowed. Then SCORAD was observed |
| As the steroids and the antihistamines were allowed to severe atopic infants aged 1-55 months, no significant difference was found between the experimental group administered with LGG and the placebo-controlled group. |
| 4 | Sistek D1 (2006) | Is the effect of probiotics on atopic dermatitis confine~~44) | 29 atopic patients who were orally administered with LGG and B. lactis lactobacillus were compared to 30 in placebo-controlled group. The SCORAD scores were checked in both groups after 2 and 12 weeks |
| After feeding the mixture of LGG and B. lactis to food-oriented atopic children, there was no difference in SCORAD score at the end of the experiment. |
| 5 | Kopp MV1 (2008) | Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention~~45) | 94 pregnant women with family history of atopic dermatitis were administered with LGG for 4-6 weeks during the pregnancy and their newborn babies were given for 6 months. Then the atopic outbreak and severity were checked for them |
| Atopic dermatitis symptoms were found in 28% of pregnant women and newborns who were administered with LGG lactobacillus while it was found in 27.3% of non-ingested group. Thus, there was no difference between the groups fed or not fed with LGG. |
| 6 | Wickens K1 (2008) | A differential effect of 2 probiotics in the prevention of eczema and atopy~~46) | L rhamnosus HN001 and B.animalis subsplactis HN019 were fed to pregnant women for 35 weeks daily and up to 6 months during the breastfeeding. Infants were also fed with the same lactobacillus for 2 years. Then, eczema and atopy were checked among them. |
| L. rhamnosus had the effect to reduce the eczema in the infants but B. animalis subsp lactis showed no effect. In contrast, both bacteria did not affect the atopy. |
| 7 | Soh SE1 (2008) | Probiotic supplementation in the first 6 months of life in at risk ~~47) | 253 children with atopic family history were fed with milk containing B.longum and L. rhamnosus for 12 months. The reference group was fed with milk without them. Then, IgE was measured. |
| Even oriental infants were fed with milk containing lactobacillus from early stages, it did not affect the development of eczema, atopy and allergies within a year. |
| 8 | Michelle Lise (2018) | Use of probiotics in atopic dermatitis48). | Lactobacillus mixtures (Bifidobacterium lactis HN019, Lactobacillus acidophilus NCFm, Lactobacillus rhamnosus HN001, Lactobacillus paracasei LPC37) was fed to the girls diagnosed with atopic dermatitis |
| After 18 months of probiotics treatment for 18-month-old female patients (hospitalized with atopic dermatitis, cleft lip, asthma, bronchiolitis), erythema and other lesions began to improve after two weeks. SCORAD, body surface area (BSA) and Family Dermatology Life Quality Index (FDLQI) were all improved. |
| 9 | Kim Min-Hye (2018) | Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles49) | 27 AD patients and 6 healthy control subjects.Lactococcus, Leuconostoc and Lactobacillus EVs were checked in the Serum of 29 Patients with Atopic Dermatitis |
| In cell experiments, IL-6 in keratinocytes and macrophages was reduced, and the extracellular vesicles derived to Lb. plantarum showed higher cell viability than those to S. aureus. |
| 10 | M. Dolores Ibanes (2018) | Effect of synbiotic supplementation on children with atopic dermatitis: an observational prospective study50) | Synbiotic supplementation (Lb.casei, Bd. lactis, Lb.rhamnosus, Lb. plantarum, fructooligosaccharides, galactooligosaccharides, biotin) were orally administered to patients with atopic dermatitis for 8 weeks |
| When synbiotic (a mixture of probiotics and prebiotics) was orally administered to children with atopic dermatitis, both SCORAD and VAS were reduced. The number of patients with moderate severity was also lowered. |
| 11 | Edyta Krzch Falta (2018) | Probiotics: Myths of facts about their role in allergy prevention51) | Lb. rhamnosus, Lb.helveticus, Trilac were orally administered to patients with food allergy, atopic dermatitis, asthma and rhinitis |
| According to the questionnaire survey for Polish people, the ingestion of live lactic acid bacteria in childhood (6-7 years) was not closely associated with atopic dermatitis, while supplementing the live lactic acid bacteria through habitual diets in adolescence (13-14 years) was more effective for allergic diseases. |
| 12 | Vicente Navarro-Lopez (2018) | Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients with Moderate Atopic Dermatitis52) | A mixture of Bifidobacterium lactis CECT 8145, B longum CECT 7347 and Lactobacillus casei CECT 9104 was orally administered to 50 patients aged 4-17 years with severe atopic dermatitis for 12 weeks. |
| Children with atopic dermatitis who ate oral probiotics mixtures had significantly lower levels of SCORAD than those who did not ingest. The amount of steroids used locally was also reduced. |
| 13 | Sofia Reddel (2019) | Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of probiotic mixture.53) | B.breve BR03 and L. salivarius LS01 were orally administered to 19 atopic dermatitis patients aged 0-16 years |
| Consuming the probiotics alone does not improve the atopic dermatitis. These probiotics are effective when the time for their transformation into beneficial bacteria in the intestine, their duration, and their balance with harmful bacteria are all met. |
| 14 | Schmidt RM1 (2019) | Probiotics in late infancy reduce the incidence of eczema : A randomized controlled trial54) | 290 preschool children were divided into a group fed with mixture of L. rhamnosus and B. animalis subsp lactis and a placebo-controlled group and tested for 6 months. |
| There was no significant difference in the incidence of eczema between the mixed Lactobacillus intake group and the placebo control group. The period of preschoolers seems to have little to do with lactic acid bacteria. |