Table 6. Changes in Nasal Endoscopy Index and Its Subgroup according to Heat and No-heat Group

Outcome	Heat pattern (N=39)		No-Heat pattern (N=19)		Group difference	p-value
	Mean	Change from baseline	Mean	Change from baseline
Nasal Endoscopy Index
Baseline	6.56 [5.66, 7.47]		6.47 [4.96, 7.99]			0.59
Week 1	5.97 [5.29, 6.66]	-0.59 [-1.38, 0.20]	6.26 [5.22, 7.30]	-0.21 [-1.17, 0.75]	-0.38 [-1.67, 0.91]
Week 2	5.56 [4.81, 6.32]	-1.00 [-1.77, -0.23]	5.79 [4.65, 6.93]	-0.68 [-1.80, 0.43]	-0.32 [-1.63, 1.00]
Week 3	4.92 [4.16, 5.69]	-1.64 [-2.38, -0.90]	5.47 [4.43, 6.52]	-1.00 [-2.09, 0.09]	-0.64 [-1.91, 0.63]
Week 4	4.97 [4.15, 5.80]	-1.59 [-2.49, -0.69]	5.32 [4.03, 6.60]	-1.16 [-2.40, 0.08]	-0.43 [-1.95, 1.09]
Nasal Endoscopy Index: Color
Baseline	1.39 [0.95, 1.82]		1.68 [1.00, 2.37]			0.32
Week 1	1.51 [1.11, 1.91]	0.13 [-0.35, 0.61]	1.47 [0.82, 2.12]	-0.21 [-1.01, 0.59]	0.34 [-0.53, 1.20]
Week 2	1.15 [0.83, 1.47]	-0.23 [-0.72, 0.26]	1.37 [0.74, 2.00]	-0.32 [-0.96, 0.33]	0.09 [-0.73, 0.90]
Week 3	1.03 [0.67, 1.39]	-0.36 [-0.80, 0.08]	1.53 [0.90, 2.16]	-0.16 [-0.92, 0.60]	-0.20 [-1.01, 0.60]
Week 4	1.03 [0.71, 1.35]	-0.36 [-0.80, 0.08]	1.26 [0.60, 1.92]	-0.42 [-0.98, 0.14]	0.06 [-0.67, 0.79]
Nasal Endoscopy Index: Atrophy Edema
Baseline	1.82 [1.44, 2.21]		1.74 [1.26, 2.22]			0.56
Week 1	1.64 [1.30, 1.99]	-0.18 [-0.57, 0.21]	1.68 [1.29, 2.08]	-0.05 [-0.66, 0.56]	-0.13 [-0.82, 0.56]
Week 2	1.62 [1.29, 1.95]	-0.21 [-0.53, 0.12]	1.21 [0.87, 1.55]	-0.53 [-1.07, 0.02]	0.32 [-0.26, 0.91]
Week 3	1.44 [1.11, 1.77]	-0.38 [-0.78, 0.01]	1.42 [1.02, 1.83]	-0.32 [-0.77, 0.14]	-0.07 [-0.70, 0.56]
Week 4	1.54 [1.18, 1.89]	-0.28 [-0.67, 0.10]	1.32 [0.89, 1.74]	-0.42 [-0.94, 0.09]	0.14 [-0.51, 0.79]
Nasal Endoscopy Index: Dryness/Dampness
Baseline	1.51 [1.18, 1.84]		1.47 [0.96, 1.99]			0.25
Week 1	1.46 [1.17, 1.76]	-0.05 [-0.41,0.31]	1.47 [1.10, 1.85]	0 [-0.58, 0.58]	-0.05 [-0.69, 0.58]
Week 2	1.36 [1.06, 1.66]	-0.15 [-0.47, 0.16]	1.90 [1.47, 2.32]	0.42 [-0.19, 1.03]	-0.57 [-1.17, 0.02]
Week 3	1.39 [1.11, 1.66]	-0.13 [-0.50, 0.25]	1.37 [0.94, 1.80]	-0.11 [-0.70, 0.49]	-0.02 [-0.69, 0.64]
Week 4	1.23 [0.92, 1.54]	-0.28 [-0.66, 0.10]	1.68 [1.18, 2.19]	0.21 [-0.42, 0.84]	-0.49 [-1.18, 0.19]
Nasal Endoscopy Index: Nasal discharge
Baseline	1.85 [1.56, 2.13]		1.58 [1.06, 2.10]			0.86
Week 1	1.36 [1.05, 1.67]	-0.49 [-0.84, -0.13]	1.63 [1.12, 2.15]	0.05 [-0.51, 0.62]	-0.54 [-1.17, 0.09]
Week 2	1.44 [1.09, 1.78]	-0.41 [-0.71, -0.11]	1.32 [0.95, 1.68]	-0.26 [-0.79, 0.27]	-0.15 [-0.70, 0.41]
Week 3	1.08 [0.80, 1.35]	-0.77 [-1.10, -0.44]	1.16 [0.72, 1.59]	-0.42 [-1.01, 0.17]	-0.35 [-0.95, 0.26]
Week 4	1.18 [0.84, 1.52]	-0.67 [-1.04, -0.29]	1.05 [0.61, 1.49]	-0.53 [-1.11, 0.06]	-0.14 [-0.80, 0.52]

Notes: Results are presented as mean [95% CI]. Mixed-effect model for repeated measure (MMRM) was used for the statistical analysis (fixed factor: group and visit, random factor: subject)