Table 5. Changes in mini-Rhinoconjunctivitis Quality of Life Questionnaire and Its Subgroup according to Heat and No-heat Group

Outcome	Heat pattern (N=39)		No-Heat pattern (N=19)		Group difference	p-value
	Mean	Change from baseline	Mean	Change from baseline
Mini-RQLQ
Baseline	41.54 [37.29, 45.79]		38.68 [31.15, 46.21]			0.74
Week 1	27.87 [23.58, 32.17]	-13.67 [-16.62, -10.71]	30.84 [25.02, 36.66]	-7.84 [-13.76, -1.92]	-5.83 [-11.57, -0.08]
Week 2	21.82 [18.75, 24.90]	-19.72 [-23.38, -16.06]	24.21 [19.89, 28.53]	-14.47 [-20.41, -8.54]	-5.24 [-11.76, 1.27]
Week 3	20.00 [16.53, 23.47]	-21.54 [-25.54, -17.54]	21.84 [16.43, 27.26]	-16.84 [-24.07, -9.61]	-4.70 [-12.13, 2.74]
Week 4	18.51 [14.87, 22.16]	-23.03 [-27.44, -18.61]	18.63 [13.87, 23.39]	-20.05 [-28.55, -11.56]	-2.97 [-11.4, 5.45]
Mini-RQLQ: Activities
Baseline	9.39 [8.32, 10.45]		8.68 [6.89, 10.48]			0.83
Week 1	7.13 [6.16, 8.10]	-2.26 [-2.99, -1.53]	7.58 [5.99, 9.17]	-1.11 [-2.11, -0.10]	-1.15 [-2.39, 0.08]
Week 2	5.92 [4.93, 6.91]	-3.46 [-4.45, -2.48]	6.63 [5.03, 8.23]	-2.05 [-3.72, -0.39]	-1.41 [-3.19. 0.37]
Week 3	5.77 [4.79, 6.75]	-3.62 [-4.63, -2.60]	6.00 [3.98, 8.02]	-2.68 [-4.85, -0.52]	-0.93 [-2.97, 1.10]
Week 4	5.21 [4.34, 6.07]	-4.18 [-5.25, -3.11]	5.32 [3.58, 7.05]	-3.37 [-5.28, -1.46]	-0.81 [-2.79, 1.17]
Mini-RQLQ: Practical problems
Baseline	7.00 [6.25, 7.75]		6.47 [5.30, 7.65]			0.63
Week 1	4.82 [4.09, 5.56]	-2.18 [-2.98, -1.38]	4.79 [3.75, 5.83]	-1.68 [-2.69, -0.68]	-0.50 [-1.81, 0.82]
Week 2	3.74 [3.16, 4.32]	-3.26 [-3.97, -2.54]	3.68 [2.86, 4.50]	-2.79 [-3.75, -1.83]	-0.47 [-1.67, 0.73]
Week 3	3.21 [2.55, 3.86]	-3.80 [-4.53, -3.06]	3.16 [2.14, 4.18]	-3.32 [-4.58, -2.05]	-0.48 [-1.82, 0.86]
Week 4	3.31 [2.65, 3.97]	-3.69 [-4.55, -2.83]	2.79 [1.83, 3.75]	-3.68 [-5.03, -2.34]	-0.01 [-1.52, 1.50]
Mini-RQLQ: Nose symptoms
Baseline	10.28 [9.22, 11.35]		9.79 [8.14, 11.44]			0.77
Week 1	7.31 [6.34, 8.28]	-2.97 [-3.93, -2.02]	7.84 [6.41, 9.27]	-1.95 [-3.38, -0.52]	-1.03 [-2.69, 0.63]
Week 2	6.00 [5.13, 6.87]	-4.28 [-5.36, -3.20]	6.32 [5.16, 7.48]	-3.47 [-4.69, -2.26]	-0.81 [-2.54, 0.93]
Week 3	5.13 [4.26, 5.99]	-5.15 [-6.39, -3.92]	5.42 [4.24, 6.61]	-4.37 [-6.04, -2.70]	-0.79 [-2.86, 1.29]
Week 4	4.51 [3.56, 5.47]	-5.77 [-7.00, -4.54]	4.84 [3.52, 6.16]	-4.95 [-6.89, -3.01]	-0.82 [-2.99, 1.34]
Mini-RQLQ: Eye symptoms
Baseline	6.80 [5.48, 8.11]		5.68 [3.53, 7.83]			0.67
Week 1	3.67 [2.52, 4.81]	-3.13 [-4.09, -2.17]	4.68 [3.19, 6.18]	-1.00 [-2.46, 0.45]	-2.13 [-3.80, -0.46]
Week 2	2.56 [1.85, 3.28]	-4.23 [-5.42, -3.05]	3.11 [1.83, 4.38]	-2.58 [-4.05, -1.10]	-1.65 [-3.60, 0.29]
Week 3	2.33 [1.60, 3.07]	-4.46 [-5.66, -3.27]	3.32 [1.42, 5.21]	-2.37 [-4.02, -0.72]	-2.09 [-4.11, -0.07]
Week 4	2.33 [1.54, 3.13]	-4.46 [-5.74, -3.19]	2.37 [1.15, 3.58]	-3.32 [-5.39, -1.25]	-1.15 [-3.42, 1.13]
Mini-RQLQ: Other symptoms
Baseline	8.08 [6.83, 9.32]		8.05 [6.01, 10.1]			0.53
Week 1	4.95 [3.71, 6.19]	-3.13 [-4.20, -2.05]	5.95 [4.35, 7.55]	-2.11 [-4.07, -0.14]	-1.02 [-3.03, 0.98]
Week 2	3.59 [2.78, 4.40]	-4.49 [-5.58, -3.40]	4.47 [3.26, 5.69]	-3.58 [-5.28, -1.88]	-0.91 [-2.82, 1.01]
Week 3	3.56 [2.51, 4.62]	-4.51 [-5.49, -3.54]	3.95 [2.65, 5.25]	-4.11 [-5.49, -2.72]	-0.41 [-2.07, 1.26]
Week 4	3.15 [2.14, 4.17]	-4.92 [-6.01, -3.84]	3.32 [2.34, 4.29]	-4.74 [-6.60, -2.87]	-0.19 [-2.16, 1.79]

Notes: Results are presented as mean [95% CI]. Mixed-effect model for repeated measure (MMRM) was used for the statistical analysis (fixed factor: group and visit, random factor: subject)
Abbreviations: RQLQ, rhinoconjunctivitis quality of life questionnaires