Table 4. Changes in Total Nasal Symptom Scores and Its Subgroup according to Heat and No-heat Group

Outcome	Heat pattern (N=39)		No-Heat pattern (N=19)		Group difference	p-value
	Mean	Change from baseline	Mean	Change from baseline
TNSS
Baseline	7.56 [7.02, 8.11]		7.05 [6.33, 7.78]			0.07
Week 1	5.64 [4.97, 6.32]	-1.92 [-2.51, -1.34]	7.16 [6.38, 7.93]	0.11 [-0.61, 0.82]	-2.03 [-3.00, -1.07]
Week 2	4.97 [4.37, 5.58]	-2.59 [-3.26, -1.92]	6.05 [5.21, 6.90]	-1.00 [-1.90, -0.11]	-1.59 [-2.71, -0.47]
Week 3	4.64 [3.97, 5.31]	-2.92 [-3.62, -2.23]	5.79 [4.81, 6.77]	-1.26 [-2.08, -0.45]	-1.66 [-2.79, -0.53]
Week 4	4.46 [3.81, 5.11]	-3.10 [-3.78, -2.43]	5.21 [4.16, 6.26]	-1.84 [-2.73, -0.96]	-1.26 [-2.38, -0.14]
TNSS: Nasal congestion
Baseline	2.31 [2.16, 2.46]		2.21 [2.01, 2.41]			0.48
Week 1	1.74 [1.51, 1.98]	-0.56 [-0.81, -0.32]	2.11 [1.75, 2.46]	-0.11 [-0.38, 0.17]	-0.46 [-0.85, -0.07]
Week 2	1.67 [1.44, 1.89]	-0.64 [-0.88, -0.40]	1.74 [1.47, 2.01]	-0.47 [-0.72, -0.23]	-0.17 [-0.55, 0.21]
Week 3	1.59 [1.35, 1.83]	-0.72 [-1.00, -0.44]	1.68 [1.32, 2.05]	-0.53 [-0.82, -0.23]	-0.19 [-0.63, 0.25]
Week 4	1.44 [1.20, 1.67]	-0.87 [-1.11, -0.63]	1.53 [1.23, 1.82]	-0.68 [-0.91, -0.45]	-0.19 [-0.56, 0.18]
TNSS: Rhinorrhea
Baseline	2.00 [1.83, 2.17]		1.84 [1.44, 2.24]			0.29
Week 1	1.62 [1.42, 1.81]	-0.38 [-0.58, -0.19]	1.90 [1.58, 2.21]	0.05 [-0.25, 0.35]	-0.44 [-0.77, -0.10]
Week 2	1.44 [1.24, 1.63]	-0.56 [-0.74, -0.39]	1.63 [1.34, 1.92]	-0.21 [-0.68, 0.26]	-0.35 [-0.76, 0.05]
Week 3	1.33 [1.15, 1.52]	-0.67 [-0.85, -0.48]	1.63 [1.30, 1.96]	-0.21 [-0.62, 0.20]	-0.46 [-0.84, -0.08]
Week 4	1.31 [1.08, 1.53]	-0.69 [-0.93, -0.46]	1.42 [1.02, 1.83]	-0.42 [-0.91, 0.07]	-0.27 [-0.74, 0.20]
TNSS: Itching
Baseline	1.54 [1.28, 1.79]		1.47 [1.04, 1.91]			0.10
Week 1	1.10 [0.84, 1.37]	-0.44 [-0.69, -0.18]	1.53 [1.23, 1.82]	0.05 [-0.32, 0.43]	-0.49 [-0.93, -0.05]
Week 2	0.85 [0.62, 1.08]	-0.69 [-0.95, -0.43]	1.32 [0.95, 1.68]	-0.16 [-0.53, 0.21]	-0.53 [-0.98, -0.09]
Week 3	0.90 [0.63, 1.16]	-0.64 [-0.91, -0.37]	1.26 [0.81, 1.71]	-0.21 [-0.62, 0.20]	-0.43 [-0.90, 0.04]
Week 4	0.85 [0.62, 1.08]	-0.69 [-0.96, -0.42]	1.16 [0.79, 1.53]	-0.32 [-0.64, 0.01]	-0.38 [-0.82, 0.06]
TNSS: Sneezing
Baseline	1.72 [1.47, 1.96]		1.53 [1.23, 1.82]			0.16
Week 1	1.18 [0.89, 1.47]	-0.54 [-0.77, -0.31]	1.63 [1.39, 1.87]	0.11 [-0.12, 0.33]	-0.64 [-1.01, -0.28]
Week 2	1.03 [0.80, 1.26]	-0.69 [-0.94, -0.44]	1.37 [1.04, 1.70]	-0.16 [-0.45, 0.13]	-0.53 [-0.94, -0.13]
Week 3	0.82 [0.59, 1.05]	-0.90 [-1.16, -0.63]	1.21 [0.91, 1.51]	-0.32 [-0.55, -0.09]	-0.58 [-0.99, -0.17]
Week 4	0.87 [0.62, 1.12]	-0.85 [-1.08, -0.62]	1.11 [0.79, 1.42]	-0.42 [-0.71, -0.13]	-0.43 [-0.80, -0.05]

Notes: Results are presented as mean [95% CI]. Mixed-effect model for repeated measure (MMRM) was used for the statistical analysis (fixed factor: group and visit, random factor: subject)
Abbreviation: TNSS, total nasal symptom score