Table 1. Clinical Trials List and Designs.

No. Title Number of gruoups Drug Control Allocation Design Masking Duration(Wks) Phase Sample size Multi-center
Internal medicine 1 The Effectiveness of Montelukast on Atopic Dermatitis in Koreans 2 Montelukast Placebo RCT Crossover Double 18 Not Applicable 54 X
2 A Study of Long-term Baricitinib (LY3009104) Therapy in Atopic Dermatitis (BREEZE-AD3) 8 Baricitinib Placebo RCT Parallel Assignment Double 16 3 1500 O
3 A Study of Baricitinib (LY3009104) in Combination With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis (BREEZE-AD7) 3 Baricitinib Placebo RCT Parallel Assignment Double 16 3 300 O
4 Study of Baricitinib (LY3009104) in Adults With Moderate to Severe Atopic Dermatitis (BREEZE-AD2) 4 Baricitinib Placebo RCT Parallel Assignment Double 16 3 750 O
5 A Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis 4 Upadacitinib Placebo RCT Parallel Assignment Double 16 3 810 X
6 Study Evaluating Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years And Older With Moderate to Severe Atopic Dermatitis (JADE Mono-2) 3 PF-04965842 Placebo RCT Parallel Assignment Double 12 3 375 O
7 Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis (JADE EXTEND) 2 PF-04965842 Placebo RCT Parallel Assignment Double 12 3 2300 O
8 Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapy (JADE Compare) 5 PF-04965842 Dupilumab Placebo RCT Parallel Assignment Double 20 3 700 O
9 Clinical trials of HH01 for adult atopic dermatitis 2 Hwanglyeonhaedok-tang Placebo RCT Parallel Assignment Double 8 3 100 X
Dermatologic agents 10 A Phase I Study of HY209 Gel in Healthy Male Volunteers for Atopic Dermatitis 7 HY209 gel Placebo RCT Parallel Assignment Double 4 1 56 X
11 A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Adults With Atopic Dermatitis 4 PAC-14028 cream Placebo RCT Parallel Assignment Double 8 2 192 X
12 CAPTAIN-AD: Clinical Study of AmorePacific's TRPV1 Antagonist in Atopic Dermatitis 2 PAC-14028 cream Placebo RCT Parallel Assignment Double 8 3 240 O
13 A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Pediatric Atopic Dermatitis 4 PAC-14028 cream Placebo RCT Parallel Assignment Double 4 1/2 56 O
14 Efficacy, Safety and Dose Finding Trial of Topical Jaungo Application in Atopic Dermatitis Patients 2 Jaungo Placebo RCT Parallel Assignment Double 4 2 34 O
15 Randomized, double-blind, multicenter, Parallel Assignment, placebo-controlled therapeutic exploratory study for the validation and safety of CP001 for patients with atopic dermatitis 3 CP001 Placebo RCT Parallel Assignment Double 8 2 144 O
16 Double-blind, randomized, placebo-controlled, Parallel Assignment, multicenter, Phase II clinical trial to assess the dose-response of HL009 in pediatric patients with mild and moderate atopic dermatitis. 4 HL-009 gel Placebo RCT Parallel Assignment Double 8 2 219 O
17 A 6-week, double-blind, randomized trial to evaluate the efficacy and safety of Elidel 1% cream for patients aged 2 to 11 years with a mild to moderate facial atopic dermatitis intolerant or dependent on topical corticosteroids , Placebo-controlled, 12-week multicenter trial consisting of a 6-week open-label trial 2 Elidel cream 1% Placebo RCT Parallel Assignment Double 12 4 200 O
injections 18 Safety and Efficacy of ADSTEM Inj. in Patients With Moderately Subacute and Chronic Atopic Dermatitis 1 ADSTEM Inj. None None RCT Parallel Assignment None 12 1 13 O
19 Safety and Efficacy of FURESTEM-AD Inj. in Patients With Moderately Subacute and Chronic Atopic Dermatitis (AD) 1 FURESTEM-AD Inj. None None RCT Parallel Assignment None 4 1/2a 34 O
20 Study of Autologous Total Immunoglobulin G Therapy for Atopic Dermatitis 2 Autologous immunoglobulin Placebo RCT Parallel Assignment Double 8 2/3 51 X
21 Safety and Efficacy of FURESTEM-AD Inj. in Patients With Moderate to Severe Chronic Atopic Dermatitis(AD) 2 FURESTEM-AD Inj. Placebo RCT Parallel Assignment Double 12 3 194 O
22 Tralokinumab Monotherapy for Moderate to Severe Atopic Dermatitis - ECZTRA 2 (ECZema TRAlokinumab Trial no. 2) (ECZTRA 2) 6 Tralokinumab Placebo RCT Parallel Assignment Double 16 3 780 O
23 Open-label Study of Dupilumab (REGN668/ SAR231893) in Patients With Atopic Dermatitis 1 Dupilumab None None RCT Parallel Assignment None 164 3 2000 O
24 Study to Assess the Efficacy and Long-term Safety of Dupilumab (REGN668/SAR231893) in Adult Participants With Moderate-to-Severe Atopic Dermatitis (CHRONOS) 3 Dupilumab Placebo RCT Parallel Assignment Double 8 3 740 O
25 A Study of Lebrikizumab in Participants With Persistent Moderate to Severe Atopic Dermatitis 4 Lebrikizumab Placebo RCT Parallel Assignment Double 12 2 212 O
26 Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis (SOLO 2) 3 Dupilumab Placebo RCT Parallel Assignment Double 16 3 708 O
27 A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic Dermatitis 4 Tezepelumab Placebo RCT Parallel Assignment Double 16 2b 300 O
28 Ⅰ/Ⅱa clinical research to evaluate the safety and effectiveness of EBI-H (Auto-derived activated lymphocyte) for subacute above medium severity and chronic atopic dermatitis patients 2 EBI-H None RCT Parallel Assignment Double 12 1/2a 23 O